Evidence map›Paper›PMID 35130040›Full record

ArticleJCO oncology practice2022

Functional Status and Survival in Older Nursing Home Residents With Advanced Non-Small-Cell Lung Cancer: A SEER-Medicare Analysis.

Michael A Liu, Tamra Keeney, Alexa Papaila, Jessica Ogarek, Humera Khurshid, Elizabeth Wulff-Burchfield, Adam Olszewski, Emmanuelle Bélanger, Orestis A Panagiotou

Open access · greenAbstract read
In one paragraph

Article in JCO oncology practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Michael A LiuWarren Alpert Medical School of Brown University, Providence, RI.
Tamra KeeneyCenter for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, RI.ORCID 0000-0002-2603-8707
Alexa PapailaWarren Alpert Medical School of Brown University, Providence, RI.ORCID 0000-0001-7148-0935
Jessica OgarekCenter for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, RI.
Humera KhurshidWarren Alpert Medical School of Brown University, Providence, RI.
Elizabeth Wulff-BurchfieldKansas University Medical Center, Kansas City, KS.ORCID 0000-0003-1474-7095
Adam OlszewskiWarren Alpert Medical School of Brown University, Providence, RI.ORCID 0000-0002-6472-6658
Emmanuelle BélangerCenter for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, RI.ORCID 0000-0001-7301-0451
Orestis A PanagiotouCenter for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, RI.ORCID 0000-0001-9604-8380
Brown University · USUniversity Medical Center · US

Funding

VARIATIONS IN LIFE'S FINAL CHAPTERP01AG027296 · NIA · BROWN UNIVERSITY · PI AMAL N. TRIVEDI · 2007 to 2026
$38.9M
CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
National Research Service AwardT32HS000011 · AHRQ · BROWN UNIVERSITY · PI TRIVEDI, AMAL N. · 1986 to 2024
$6.1M
Which Post-Acute Care Setting is Best for Patients' Outcomes?R01AG054656 · NIA · BROWN UNIVERSITY · PI GOZALO, PEDRO L, GRABOWSKI, DAVID C · 2017 to 2019
$1.7M
AHRQ HHS T32 HS000011NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNIA NIH HHS P01 AG027296NIA NIH HHS R01 AG054656
6 · The paper itself

Abstract

purposeMany older patients with advanced lung cancer have functional limitations and require skilled nursing home care. Function, assessed using activities of daily living (ADL) scores, may help prognostication. We investigated the relationship between ADL impairment and overall survival among older patients with advanced non-small-cell lung cancer (NSCLC) receiving care in nursing homes.

methodsUsing the SEER-Medicare database linked with Minimum Data Set assessments, we identified patients age 65 years and older with NSCLC who received care in nursing homes from 2011 to 2015. We used Cox regression and Kaplan-Meier survival curves to examine the relationship between ADL scores and overall survival among all patients; among patients who received systemic cancer chemotherapy or immunotherapy within 3 months of NSCLC diagnosis; and among patients who did not receive any treatment.

resultsWe included 3,174 patients (mean [standard deviation] age, 77 [7.4] years [range, 65-102 years]; 1,664 [52.4%] of female sex; 394 [12.4%] of non-Hispanic Black race/ethnicity), 415 (13.1%) of whom received systemic therapy, most commonly with carboplatin-based regimens (n = 357 [86%] patients). The median overall survival was 3.1 months for patients with ADL score < 14, 2.8 months for patients with ADL score between 14 and 17, 2.3 months for patients with ADL score between 18-19, and 1.8 months for patients with ADL score 20+ (log-rank

conclusionADL assessment stratified mortality outcomes among older nursing home adults with NSCLC, and may be a useful clinical consideration in this population.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsActivities of Daily LivingAgedFemaleFunctional StatusHumansMedicareNursing HomesUnited States

Identifiers

PMID35130040
PMCPMC9191367
OpenAlexW4210844365

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.