Evidence map›Paper›PMID 35136160›Full record

Trial reportScientific reports2022

A graphical LASSO analysis of global quality of life, sub scales of the EORTC QLQ-C30 instrument and depression in early breast cancer.

Paula Poikonen-Saksela, Eleni Kolokotroni, Leena Vehmanen, Johanna Mattson, Georgios Stamatakos, Riikka Huovinen, Pirkko-Liisa Kellokumpu-Lehtinen, Carl Blomqvist, Tiina Saarto

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00639210 (BREAST CANCER AND EXERCISE BREX), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00639210 phase3completednot on this map

BREAST CANCER AND EXERCISE BREX: A Multicenter Phase III Open Randomised Trial of the Efficacy of Exercise in the Prevention of Long-term Adverse Effects of Adjuvant Treatments and Breast Cancer Recurrences in Women With Primary Breast Cancer.

TypeinterventionalSponsorFinnish Breast Cancer GroupRan2005 to 2007Enrolled573ConditionsPrevent Osteoporosis and Osteoporotic Fractures, Improve Quality of Life, Improve Weight Control, and Muscular and Cardiovascular Fitness, Help the Patients to Return to Working LifeArmssupervised training
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

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  11. Lung cancer-specific symptoms and fear of cancer recurrence among recurrence-free non-small cell lung cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Paula Poikonen-Saksela *Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. paula.poikonen-saksela@hus.fi.
Eleni Kolokotroni *In Silico Oncology and In Silico Medicine Group, Institute of Communication and Computer Systems, School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.
Leena VehmanenComprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Johanna MattsonComprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Georgios StamatakosIn Silico Oncology and In Silico Medicine Group, Institute of Communication and Computer Systems, School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.
Riikka HuovinenDepartment of Oncology, Turku University Hospital and Faculty of Medicine, University of Turku, Turku, Finland.
Pirkko-Liisa Kellokumpu-LehtinenFaculty of Medicine and Health Technology, Tampere University and Research, Development and Innovation Center, Tampere University Hospital, Tampere, Finland.
Carl BlomqvistComprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Tiina SaartoComprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
University of Helsinki · FIHelsinki University Hospital · FIInstitute of Communication and Computer Systems · GRNational Technical University of Athens · GRTampere University · FITurku University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to (a) investigate the interplay between depression, symptoms and level of functioning, and (b) understand the paths through which they influence health related quality of life (QOL) during the first year of rehabilitation period of early breast cancer. A network analysis method was used. The population consisted of 487 women aged 35-68 years, who had recently completed adjuvant chemotherapy or started endocrine therapy for early breast cancer. At baseline and at the first year from randomization QOL, symptomatology and functioning by the EORTC QLQ-C30 and BR-23 questionnaires, and depression by the Finnish version of Beck's 13-item depression scale, were collected. The multivariate interplay between the related scales was analysed via regularized partial correlation networks (graphical LASSO). The median global quality of life (gQoL) at baseline was 69.9 ± 19.0 (16.7-100) and improved to 74.9 ± 19.0 (0-100) after 1 year. Scales related to mental health (emotional functioning, cognitive functioning, depression, insomnia, body image, future perspective) were clustered together at both time points. Fatigue was mediated through a different route, having the strongest connection with physical functioning and no direct connection with depression. Multiple paths existed connecting symptoms and functioning types with gQoL. Factors with the strongest connections to gQoL included: social functioning, depression and fatigue at baseline; emotional functioning and fatigue at month 12. Overall, the most important nodes were depression, gQoL and fatigue. The graphical LASSO network analysis revealed that scales related to fatigue and emotional health had the strongest associations to the EORTC QLQ-C30 gQoL score. When we plan interventions for patients with impaired QOL it is important to consider both psychological support and interventions that improve fatigue and physical function like exercise.Trial registration: http://www.clinicaltrials.gov/ (identifier number NCT00639210).

Indexed as

Quality of LifeAdultAgedBreast NeoplasmsDepressionFemaleFollow-Up StudiesHumansMiddle AgedRegression Analysis

Identifiers

PMID35136160
PMCPMC8826362
OpenAlexW4210923946

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.