ArticleHypertension (Dallas, Tex. : 1979)2022
Maternal Hypertension Increases Risk of Preeclampsia and Low Fetal Birthweight: Genetic Evidence From a Mendelian Randomization Study.
Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Maternal adiposity and perinatal and offspring outcomes: an umbrella review.Nature human behaviour · 2024Pooled it
- Investigating genetic links between blood metabolites and preeclampsia.BMC women's health · 2024Pooled it
- Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study.BMC medicine · 2024Pooled it
- Pooled it
- Association of Maternal Overweight/Obesity Metabolic Phenotypes With Longitudinal Foetal Anthropometric Measurements.Diabetes, obesity & metabolism · 2026Article
- Maternal multimorbidity, lifestyle behaviours during pregnancy, and early-childhood growth trajectories: a register-based cohort study.The Lancet regional health. Western Pacific · 2026Article
- Effects of Genetically-Proxied Antihypertensive Drug Targets on Preeclampsia and Birth Weight.medRxiv : the preprint server for health sciences · 2026Article
- Trimester-specific gestational weight gain and adverse outcomes in GDM women: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Causal Effects of Common Pregnancy Complications on Neonatal Birth Weight: A Mendelian Randomization Study.International journal of women's health · 2026Article
- Prevalence and maternal risk factors of small for gestational age infants born at a regional centre in Australia: a retrospective study.Translational pediatrics · 2025Article
- Elevated Pre-Pregnancy Blood Pressure and the Risk of Adverse Pregnancy Outcomes: Evidence From a Nationwide Population-Based Study.Journal of Korean medical science · 2025Article
- Does Maternal Location of Residence Affect Low Birth Weight Outcomes in Hunter New England Local Health District?The Australian & New Zealand journal of obstetrics & gynaecology · 2025Article
- Prediction of birthweight with early and mid-pregnancy antenatal markers utilising machine learning and explainable artificial intelligence.Scientific reports · 2025Article
- Anxiety and hypertensive disorders of pregnancy: Epidemiology, mechanisms, and management strategies.World journal of psychiatry · 2025Review
- Epidemiology and Pathophysiology of Preeclampsia: New Mechanistic Insights.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Article
- Novel insights into causal effects of maternal nonalcoholic fatty liver disease on adverse pregnancy outcomes: evidence from Human Genetics and Mendelian Randomization Study.European journal of clinical nutrition · 2024Article
- A Comparison of Apelin Rs56204867 and Apelin Receptor Rs11544374 Gene Polymorphisms and Their Association with Risk of Preeclampsia in Southeast Iran.Reports of biochemistry & molecular biology · 2024Article
- Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study.Heart (British Cardiac Society) · 2024Article
- Sex-based differences in risk factors for incident myocardial infarction and stroke in the UK Biobank.European heart journal. Quality of care & clinical outcomes · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMaternal cardiovascular risk factors have been associated with adverse maternal and fetal outcomes. Given the difficulty in establishing causal relationships using epidemiological data, we applied Mendelian randomization to explore the role of cardiovascular risk factors on risk of developing preeclampsia or eclampsia, and low fetal birthweight.
methodsUncorrelated single-nucleotide polymorphisms associated systolic blood pressure (SBP), body mass index, type 2 diabetes, LDL (low-density lipoprotein) with cholesterol, smoking, urinary albumin-to-creatinine ratio, and estimated glomerular filtration rate at genome-wide significance in studies of 298 957 to 1 201 909 European ancestry participants were selected as instrumental variables. A 2-sample Mendelian randomization study was performed with primary outcome of preeclampsia or eclampsia (PET). Risk factors associated with PET were further investigated for their association with low birthweight.
resultsHigher genetically predicted SBP was associated increased risk of PET (odds ratio [OR] per 1-SD SBP increase 1.90 [95% CI=1.45-2.49];
conclusionsOur results provide evidence for causal effects of SBP, body mass index, and type 2 diabetes on PET and identify that SBP is associated with reduced birthweight independently of PET. The results provide insight into the pathophysiological basis of PET and identify hypertension as a potentially modifiable risk factor amenable to therapeutic intervention.
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