Evidence map›Paper›PMID 35140402›Full record

ArticleNature2022

Mechanisms of inhibition and activation of extrasynaptic αβ GABA

Vikram Babu Kasaragod, Martin Mortensen, Steven W Hardwick, Ayla A Wahid, Valentina Dorovykh, Dimitri Y Chirgadze, Trevor G Smart, Paul S Miller

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
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  11. Review
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  13. Article
  14. Article
  15. GABAiScience · 2025
    Article
  16. Deep Learning-Based Ion Channel Kinetics Analysis for Automated Patch Clamp Recording.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  17. GABAMolecular cell · 2025
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Vikram Babu KasaragodDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Martin MortensenDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID http://orcid.org/0000-0002-5873-7107
Steven W HardwickCryo-EM Facility, Department of Biochemistry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9246-1864
Ayla A WahidDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8128-9632
Valentina DorovykhDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Dimitri Y ChirgadzeCryo-EM Facility, Department of Biochemistry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9942-0993
Trevor G SmartDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK. t.smart@ucl.ac.uk.ORCID http://orcid.org/0000-0002-9089-5375
Paul S MillerDepartment of Pharmacology, University of Cambridge, Cambridge, UK. pm676@cam.ac.uk.ORCID http://orcid.org/0000-0002-6512-9441
University of Cambridge · GBUniversity College London · GBMRC Laboratory of Molecular Biology · GBThe London College · GB

Funding

Academy of Medical SciencesMedical Research Council MR/T002581/1Wellcome TrustWellcome Trust 202905/Z/16/ZWellcome Trust 206171/Z/17/Z
6 · The paper itself

Abstract

Type A GABA (γ-aminobutyric acid) receptors represent a diverse population in the mammalian brain, forming pentamers from combinations of α-, β-, γ-, δ-, ε-, ρ-, θ- and π-subunits

Indexed as

GABA-A Receptor AgonistsGABA-A Receptor AntagonistsReceptors, GABA-AAnimalsCobra Neurotoxin Proteinsgamma-Aminobutyric AcidHumansMammalsNeural InhibitionNeuronsSynapsesZincalpha-cobratoxinCobra Neurotoxin ProteinsGABA-A Receptor AgonistsGABA-A Receptor Antagonistsgamma-Aminobutyric AcidReceptors, GABA-AZinc

Identifiers

PMID35140402
PMCPMC8850191
OpenAlexW4210865559

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.