Evidence map›Paper›PMID 35145373›Full record

ReviewFrontiers in neuroscience2021

Potential Mechanisms of Acupuncture for Functional Dyspepsia Based on Pathophysiology.

Na-Na Yang, Chun-Xia Tan, Lu-Lu Lin, Xin-Tong Su, Yue-Jie Li, Ling-Yu Qi, Yu Wang, Jing-Wen Yang, Cun-Zhi Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Na-Na YangInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China.
Chun-Xia TanInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China.
Lu-Lu LinInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China.
Xin-Tong SuInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China.
Yue-Jie LiInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China.
Ling-Yu QiInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China.
Yu WangInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China.
Jing-Wen YangInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China.
Cun-Zhi LiuInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China.
Beijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional dyspepsia (FD), a common disorder of gastrointestinal function, originated from the gastroduodenum. Although the therapeutic effect of acupuncture has been investigated by various high-quality randomized controlled trials, the potential mechanisms showed obvious heterogeneity. This review summarized the potential mechanisms of acupuncture on FD in order to guide for future laboratory and clinical studies. Here, we argued that the primary cause of FD was gastroduodenal low-grade inflammation and acid exposure, which impaired mucosal integrity, caused brain-gut axis dysfunction, and impaired brain network connectivity, all of which generated various symptom patterns. Overall the clinical studies indicated that acupuncture was a promising treatment to alleviate symptoms in FD patients, whose efficacy was influenced by acupoints and individual variance. Mechanistically, studies with animal models of FD and patients have shown that acupuncture, a non-invasive strategy for nerve stimulation, may have the potential to control intestinal inflammation and suppress acid-secretion via different somatic autonomic reflex pathways, regulate the brain-gut axis through intestinal microbiota, and has the potential to ameliorate FD-symptoms. The cumulative evidence demonstrated that acupuncture is a promising treatment to alleviate symptoms of FD patients.

Indexed as

acid exposureacupuncturebrain-gut axisfunctional dyspepsialow-grade inflammation

Identifiers

PMID35145373
PMCPMC8822151
OpenAlexW4206930677

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.