Evidence map›Paper›PMID 35147496›Full record

ArticleeLife2022

Multiple motors cooperate to establish and maintain acentrosomal spindle bipolarity in

Gabriel Cavin-Meza, Michelle M Kwan, Sarah M Wignall

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Acentrosomal spindle assembly and maintenance inMolecular biology of the cell · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gabriel Cavin-MezaDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.ORCID 0000-0001-5820-4071
Michelle M KwanDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.
Sarah M WignallDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.ORCID 0000-0001-9828-9356

Funding

CARCINOGENESIS TRAINING PROGRAMT32CA009560 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1986 to 2026
$8.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Regulation of chromosome segregation during oocyte meiosisR01GM124354 · NIGMS · NORTHWESTERN UNIVERSITY · PI SARAH Marie WIGNALL · 2018 to 2026
$2.8M
Mechanisms of acentrosomal spindle assembly and stability during oocyte meiosisR01GM141386 · NIGMS · NORTHWESTERN UNIVERSITY · PI WIGNALL, SARAH MARIE · 2022 to 2025
$1.5M
NCI NIH HHS T32 CA009560NIGMS NIH HHS R01 GM124354NIGMS NIH HHS R01 GM141386NIH HHS P40 OD010440
6 · The paper itself

Abstract

While centrosomes organize spindle poles during mitosis, oocyte meiosis can occur in their absence. Spindles in human oocytes frequently fail to maintain bipolarity and consequently undergo chromosome segregation errors, making it important to understand the mechanisms that promote acentrosomal spindle stability. To this end, we have optimized the auxin-inducible degron system in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsKinesinsMeiosisMicrotubulesOocytesSpindle ApparatusCaenorhabditis elegans ProteinsKinesinsKLP-18 protein, C elegansacentrosomalC. eleganscell biologygeneticsgenomicsmeiosismicrotubulemotoroocytespindle

Identifiers

PMID35147496
PMCPMC8963883
OpenAlexW4211065954

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.