ArticleProceedings of the National Academy of Sciences of the United States of America2022
Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling.
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- The impactful role of the HDACs in the regulation of gene expression and as targets for disease therapy.Science advances · 2026Review
- Protein lipidation in cardiovascular homeostasis, development, and disease.Clinical science (London, England : 1979) · 2026Review
- Hdac11 promotes idiopathic pulmonary fibrosis through macrophage M2-type polarization and myofibroblast accumulation by inhibiting Parkin-dependent mitophagy.Nature communications · 2026Article
- Phosphodiesterase 8 regulation of excitation-contraction coupling as a target for cardiovascular disease: is it my turn now?American journal of physiology. Heart and circulatory physiology · 2026Review
- A small‑molecule HDAC/PDE modulator activates human adipocyte UCP1 and resolves inflammatory signaling.Journal of translational medicine · 2026Article
- HDAC11 Regulates RNA Splicing via De-Fatty Acylation of SF3B2.bioRxiv : the preprint server for biology · 2026Article
- Processes and therapeutic perspectives of acylation modifications of lysine and cysteine in tumors.Cell communication and signaling : CCS · 2026Review
- HDAC11 Deacetylates BRAF to Regulate Kinase Activity and Cell Proliferation.ACS chemical biology · 2025Article
- Lysine myristoylation mediates long-term potentiation via membrane enrichment of synaptic plasticity effectors.The EMBO journal · 2025Article
- HDAC11 deficiency regulates age-related muscle decline and sarcopenia.GeroScience · 2025Article
- Article
- Identification of Critical Molecular Pathways Induced by HDAC11 Overexpression in Cardiac Mesenchymal Stem Cells.Biomolecules · 2025Article
- Membrane Association of Intrinsically Disordered Proteins.Annual review of biophysics · 2025Review
- Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
- Gravi-D peptide disrupts HDAC11 association with an AKAP to stimulate adipocyte thermogenic signaling.The Journal of clinical investigation · 2024Article
- AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.Circulation research · 2024Article
- Protein lipidation in health and disease: molecular basis, physiological function and pathological implication.Signal transduction and targeted therapy · 2024Review
- Emerging role of HDAC11 in skeletal muscle biology.Frontiers in cell and developmental biology · 2024Article
- HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance.The Journal of clinical investigation · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 1 country.
Rushita A BagchiDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045-2507.
Emma L RobinsonDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045-2507.
Tianjing HuDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045-2507.
Ji CaoDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-2813-6404
Jun Young HongDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Charles A TharpDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045-2507.ORCID 0000-0002-0653-4105
Hanan QasimDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204-5037.ORCID 0000-0002-0981-2051
Kathleen M GavinDepartment of Medicine, Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045-2507.
Julie Pires da SilvaDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045-2507.ORCID 0000-0002-7718-7892
Jennifer L MajorDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045-2507.
Bradley K McConnellDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204-5037.ORCID 0000-0001-8712-0336
Edward SetoDepartment of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC 20037.
Hening LinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-0255-2701
Timothy A McKinseyDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045-2507; timothy.mckinsey@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · USCornell University · USUniversity of Houston · USGeorge Washington University · USGeriatric Research Education and Clinical Center · US
Funding
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6MUniversity of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8MZEBRAFISH TRANSGENIC CORE - ROCKY MOUNTAIN NEUROLOGICAL DISORDERS CORE CENTERP30NS048154 · NINDS · UNIVERSITY OF COLORADO DENVER · PI RIBERA, ANGELES BADELL · 2004 to 2020
$10.1MRegulation of Chromatin Signaling in Heart Failure by the BRD4 Bromodomain Protein.R01HL127240 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MCKINSEY, TIMOTHY, SRIVASTAVA, DEEPAK · 2015 to 2022
$6.4MPOSTGRADUATE TRAINING IN CARDIOVASCULAR RESEARCHT32HL007822 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUTTRICK, PETER N., LEINWAND, LESLIE ANNE · 1996 to 2023
$6.2MDeacetylase-Dependent Control of Diastolic Dysfunction and HFpEFR01HL147558 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HOUSER, STEVEN R, MCKINSEY, TIMOTHY · 2019 to 2022
$3.1MRegulation of Cardiac Signaling by Class I Histone DeacetylasesR01HL116848 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MCKINSEY, TIMOTHY · 2013 to 2021
$3.1MSmall molecule therapies targeting chromatin architecture in heart failureR01HL150225 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCKINSEY, TIMOTHY, VONDRISKA, THOMAS M. · 2020 to 2023
$2.9MScreening and Development of Small Molecule HDAC11 Inhibitors to Treat Obesity and Diabetes.R01DK119594 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LIN, HENING, MCKINSEY, TIMOTHY · 2019 to 2022
$2.1MAcquisition of a supercontinuum laser STED microscopeS10RR023381 · NCRR · UNIVERSITY OF COLORADO DENVER · PI RESTREPO, DIEGO · 2010 to 2010
$468kGravin Signalosome Protein Coordinates Cardiac Function via Adrenergic Receptor SignalingR15HL141963 · NHLBI · UNIVERSITY OF HOUSTON · PI MCCONNELL, BRADLEY K · 2019 to 2019
$459kTargeting HDAC6 to Modulate Titin Stiffness for Dilated Cardiomyopathy TherapyR43HL154959 · NHLBI · EIKONIZO THERAPEUTICS, INC. · PI SCHROEDER, FREDERICK ALBERT · 2020 to 2020
$300kNCRR NIH HHS S10 RR023381NHLBI NIH HHS R01 HL116848NHLBI NIH HHS R01 HL127240NHLBI NIH HHS R01 HL147558NHLBI NIH HHS R01 HL150225NHLBI NIH HHS R15 HL141963NHLBI NIH HHS R43 HL154959NHLBI NIH HHS T32 HL007822NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK119594NINDS NIH HHS P30 NS048154
Abstract
PubMed holds no abstract for this paper.
Indexed as
3T3-L1 CellsAcylationAdipocytesAnimalsGene Expression RegulationHistone DeacetylasesHumansLysineMaleMiceMice, Inbred C57BLMice, KnockoutHdac11 protein, mouseHistone DeacetylasesLysineadrenergic receptorHDAC11lysine myristoylationsignal transduction
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What Socratic holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.