Evidence map›Paper›PMID 35149937›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2022

Cardiac sympathetic innervation in Parkinson's disease versus multiple system atrophy.

Christine Eckhardt, Florian Krismer, Eveline Donnemiller, Sabine Eschlböck, Alessandra Fanciulli, Cecilia Raccagni, Sylvia Bösch, Katherina Mair, Christoph Scherfler, Atbin Djamshidian and 7 more

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In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. The role of neuro-imaging in multiple system atrophy.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
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  7. Value of multi-parameterEJNMMI research · 2025
    Article
  8. Article
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  11. What new can we learn from cardiac sympathetic neuroimaging in synucleinopathies?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 1 institution in 2 countries.

Christine EckhardtDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Florian KrismerDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria. florian.krismer@i-med.ac.at.ORCID 0000-0002-4493-5073
Eveline DonnemillerDepartment of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Sabine EschlböckDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Alessandra FanciulliDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Cecilia RaccagniDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Sylvia BöschDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Katherina MairDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Christoph ScherflerDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Atbin DjamshidianDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Christian UprimnyDepartment of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Bernhard MetzlerDepartment of Internal Medicine, Cardiology and Angiology, Medical University Innsbruck, Innsbruck, Austria.
Klaus SeppiDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Werner PoeweDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Stefan KiechlDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Irene VirgoliniDepartment of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Gregor K WenningDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria. gregor.wenning@i-med.ac.at.
Innsbruck Medical University · AT

Funding

Austrian Science Fund FWF KLI 380
6 · The paper itself

Abstract

purposeThe aims of this study were to evaluate the diagnostic accuracy of the dual imaging method combining cardiac iodine-

methodsA prospective study including 19 Parkinson's disease and 12 multiple system atrophy patients was performed. Patients underwent clinical evaluation, iodine-

resultsCo-registration of single-photon emission computed tomography and chest computed tomography resulted in three groups with distinct patterns of tracer uptake: homogeneous, non-homogeneously reduced and absent. There was a significant difference in group allocation among patients with multiple system atrophy and Parkinson's disease (p = 0.001). Most multiple system atrophy patients showed homogeneous uptake, and the majority of Parkinson's disease patients showed absent cardiac tracer uptake. We identified a pattern of heterogeneous cardiac tracer uptake in both diseases with reductions in the apex and the lateral myocardial wall. Sympathetic dysfunction reflected by a missing blood pressure overshoot during Valsalva manoeuvre correlated with cardiac tracer distribution in Parkinson's disease patients (p < 0.001).

conclusionsThe diagnostic accuracy of the dual imaging method and routine cardiac scintigraphy were similar. Anatomical tracer allocation provided by the dual imaging method of cardiac iodine-

Indexed as

IodineMultiple System AtrophyParkinson Disease3-IodobenzylguanidineHumansProspective Studies3-IodobenzylguanidineIodineAutonomic functionCardiac sympathetic denervationMultiple system atrophyParkinsonismParkinson’s disease

Identifiers

PMID35149937
PMCPMC9064856
OpenAlexW4210954004

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.