ArticleCurrent biology : CB2022
Complementary roles of serotonergic and cholinergic systems in decisions about when to act.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 29 citations in OpenAlex.
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- A brain-wide, trial- and time-dependent deterministic drive synergizes with within-trial noise to time self-initiated actions.bioRxiv : the preprint server for biology · 2026Article
- Activity in human dorsal raphe nucleus signals changes in behavioural policy.Nature communications · 2026Article
- Humans are more prosocial in poor foraging environments.Nature communications · 2026Article
- Fundamental features of social environments determine rate of social affiliation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dorsal raphe nucleus controls motivation-state transitions in monkeys.Science advances · 2025Article
- Complementary roles of serotonin and dopamine in model-based learning.Current opinion in behavioral sciences · 2025Article
- A distributed subcortical circuit linked to instrumental information-seeking about threat.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- General mechanisms of task engagement in the primate frontal cortex.Nature communications · 2024Article
- Neural activity ramps in frontal cortex signal extended motivation during learning.bioRxiv : the preprint server for biology · 2024Article
- Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Dynamic off-resonance correction improves functional image analysis in fMRI of awake behaving non-human primates.Frontiers in neuroimaging · 2024Article
- Dorsal raphe neurons signal integrated value during multi-attribute decision-making.bioRxiv : the preprint server for biology · 2023Article
- Fluoxetine degrades luminance perceptual thresholds while enhancing motivation and reward sensitivity.Frontiers in pharmacology · 2023Article
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Abstract
Decision-making not only involves deciding about which action to choose but when and whether to initiate an action in the first place. Macaque monkeys tracked number of dots on a screen and could choose when to make a response. The longer the animals waited before responding, the more dots appeared on the screen and the higher the probability of reward. Monkeys waited longer before making a response when a trial's value was less than the environment's average value. Recordings of brain activity with fMRI revealed that activity in dorsal raphe nucleus (DRN)-a key source of serotonin (5-HT)-tracked average value of the environment. By contrast, activity in the basal forebrain (BF)-an important source of acetylcholine (ACh)-was related to decision time to act as a function of immediate and recent past context. Interactions between DRN and BF and the anterior cingulate cortex (ACC), another region with action initiation-related activity, occurred as a function of the decision time to act. Next, we performed two psychopharmacological studies. Manipulating systemic 5-HT by citalopram prolonged the time macaques waited to respond for a given opportunity. This effect was more evident during blocks with long inter-trial intervals (ITIs) where good opportunities were sparse. Manipulating systemic acetylcholine (ACh) by rivastigmine reduced the time macaques waited to respond given the immediate and recent past context, a pattern opposite to the effect observed with 5-HT. These findings suggest complementary roles for serotonin/DRN and acetylcholine/BF in decisions about when to initiate an action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.