Evidence map›Paper›PMID 35154499›Full record

ArticleTheranostics2022

Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids.

Laurent Vachon, Ali Smaani, Nolwenn Tessier, Gabriel Jean, Annie Demers, Andreea Milasan, Nadine Ardo, Stéphanie Jarry, Louis Villeneuve, Azadeh Alikashani and 5 more

Open access · goldFull text read
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Laurent VachonDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Ali SmaaniDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Nolwenn TessierDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Gabriel JeanDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Annie DemersMontreal Heart Institute, Research Center, Montreal, Quebec, Canada.
Andreea MilasanDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Nadine ArdoMontreal Heart Institute, Research Center, Montreal, Quebec, Canada.
Stéphanie JarryDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Louis VilleneuveMontreal Heart Institute, Research Center, Montreal, Quebec, Canada.
Azadeh AlikashaniMontreal Heart Institute, Research Center, Montreal, Quebec, Canada.
Vincent FinhertyMontreal Heart Institute, Research Center, Montreal, Quebec, Canada.
Matthieu RuizDepartment of Nutrition, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Mary G Sorci-ThomasDepartment of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Gaétan MayerMontreal Heart Institute, Research Center, Montreal, Quebec, Canada.
Catherine MartelDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Montreal Heart Institute · CAUniversité de Montréal · CAMedical College of Wisconsin · US

Funding

SR-BI and PCPE2: Novel partners in bi-directional cholesterol transportR01HL138907 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SAHOO, DAISY, SORCI-THOMAS, MARY G · 2018 to 2021
$2.8M
NHLBI NIH HHS R01 HL138907
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AtherosclerosisHyperlipidemiasAnimalsCholesterolDown-RegulationEndothelial CellsLipidsLipoproteins, LDLMiceMice, Inbred C57BLMice, KnockoutProprotein Convertase 9RNA, MessengerVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3CholesterolLipidsLipoproteins, LDLPCSK9 protein, humanProprotein Convertase 9RNA, MessengerVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3AtherosclerosisLDLRLymphatic dysfunctionLymphatic SystemPCSK9

Identifiers

PMID35154499
PMCPMC8771568
OpenAlexW4205644411

What Socratic holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.