Evidence map›Paper›PMID 35155211›Full record

ReviewFrontiers in oncology2021

Interaction of ncRNA and Epigenetic Modifications in Gastric Cancer: Focus on Histone Modification.

Qingfan Yang, Yu Chen, Rui Guo, Yalan Dai, Liyao Tang, Yueshui Zhao, Xu Wu, Mingxing Li, Fukuan Du, Jing Shen and 3 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Role of histone modifications in gastric cancer (Review).International journal of oncology · 2026
    Review
  7. The Prognostic and Biological Value of PGF-Based H&E Pathomics in Hepatocellular Carcinoma.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Regulation of RNA methylation linked to drug resistance in gastric cancer.Frontiers in cell and developmental biology · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Qingfan YangDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou, China.
Yu ChenSouth Sichuan Institute of Translational Medicine, Luzhou, China.
Rui GuoDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou, China.
Yalan DaiDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou, China.
Liyao TangLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.
Yueshui ZhaoSouth Sichuan Institute of Translational Medicine, Luzhou, China.
Xu WuSouth Sichuan Institute of Translational Medicine, Luzhou, China.
Mingxing LiSouth Sichuan Institute of Translational Medicine, Luzhou, China.
Fukuan DuSouth Sichuan Institute of Translational Medicine, Luzhou, China.
Jing ShenSouth Sichuan Institute of Translational Medicine, Luzhou, China.
Tao YiSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong SAR, China.
Zhangang XiaoSouth Sichuan Institute of Translational Medicine, Luzhou, China.
Qinglian WenDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou, China.
Affiliated Hospital of Southwest Medical University · CNFirst Affiliated Hospital of Sichuan Medical University · CNShanghai Cell Therapy Research Institute · CNSouthwest Medical University · CNHong Kong Baptist University · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer has developed as a very common gastrointestinal tumors, with recent effective advancements in the diagnosis and treatment of early gastric cancer. However, the prognosis for gastric cancer remains poor. As a result, there is in sore need of better understanding the mechanisms of gastric cancer development and progression to improve existing diagnostic and treatment options. In recent years, epigenetics has been recognized as an important contributor on tumor progression. Epigenetic changes in cancer include chromatin remodeling, DNA methylation and histone modifications. An increasing number of studies demonstrated that noncoding RNAs (ncRNAs) are associated with epigenetic changes in gastric cancer. Herein, we describe the molecular interactions of histone modifications and ncRNAs in epigenetics. We focus on ncRNA-mediated histone modifications of gene expression associated with tumorigenesis and progression in gastric cancer. This molecular mechanism will contribute to our deeper understanding of gastric carcinogenesis and progression, thus providing innovations in gastric cancer diagnosis and treatment strategies.

Indexed as

epigenetic modificationsgastric cancerhistone modificationmechanismsncRNA

Identifiers

PMID35155211
PMCPMC8826423
OpenAlexW4210816351

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.