Evidence map›Paper›PMID 35158347›Full record

ArticlePhysical biology2022

Tumor spheroid invasion in epidermal growth factor gradients revealed by a 3D microfluidic device.

Young Joon Suh, Mrinal Pandey, Jeffrey E Segall, Mingming Wu

Open access · greenAbstract read
In one paragraph

Article in Physical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Microphysiological systems for metastasis research: a stepwise approach.Cellular oncology (Dordrecht, Netherlands) · 2025
    Review
  4. Article
  5. Nanoplasmonic Single-Tumoroid Microarray for Real-Time Secretion Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Young Joon SuhDepartment of Biological and Environmental Engineering, 306 Riley-Robb Hall, Cornell University, Ithaca, NY 14853, United States of America.ORCID 0000-0002-8281-3042
Mrinal PandeyDepartment of Biological and Environmental Engineering, 306 Riley-Robb Hall, Cornell University, Ithaca, NY 14853, United States of America.ORCID 0000-0001-8941-4290
Jeffrey E SegallAnatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, United States of America.ORCID 0000-0001-5425-9315
Mingming WuDepartment of Biological and Environmental Engineering, 306 Riley-Robb Hall, Cornell University, Ithaca, NY 14853, United States of America.ORCID 0000-0001-7846-3580
Cornell University · USAlbert Einstein College of Medicine · US

Funding

TRANS-NETWORK PROJECTSU54CA143876 · NCI · CORNELL UNIVERSITY · PI SHULER, MICHAEL L · 2009 to 2014
$12.6M
Microfluidic platform for tumor cell invasionR01CA221346 · NCI · CORNELL UNIVERSITY · PI Mingming Wu · 2017 to 2026
$3.4M
NCI NIH HHS R01 CA221346NCI NIH HHS U54 CA143876
6 · The paper itself

Abstract

Epidermal growth factor (EGF), a potent cytokine, is known to promote tumor invasion both

Indexed as

Epidermal Growth FactorLab-On-A-Chip DevicesAnimalsCell Line, TumorChemotaxisCollagenMammalsSpheroids, CellularCollagenEpidermal Growth Factor3D ECMchemotaxisEGFinvasionmicrofluidicstumor microenvironmenttumor spheroid

Identifiers

PMID35158347
PMCPMC8957059
OpenAlexW4213168071

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.