Evidence map›Paper›PMID 35159004›Full record

ArticleCancers2022

Primary Tumor Resection Decelerates Disease Progression in an Orthotopic Mouse Model of Metastatic Prostate Cancer.

Johannes Linxweiler, Turkan Hajili, Philip Zeuschner, Michael D Menger, Michael Stöckle, Kerstin Junker, Matthias Saar

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Johannes LinxweilerDepartment of Urology, Saarland University, 66421 Homburg, Saar, Germany.
Turkan HajiliDepartment of Urology, Saarland University, 66421 Homburg, Saar, Germany.
Philip ZeuschnerDepartment of Urology, Saarland University, 66421 Homburg, Saar, Germany.ORCID 0000-0001-8898-6588
Michael D MengerInstitute for Clinical-Experimental Surgery, Saarland University, 66421 Homburg, Saar, Germany.ORCID 0000-0002-9670-7961
Michael StöckleDepartment of Urology, Saarland University, 66421 Homburg, Saar, Germany.
Kerstin JunkerDepartment of Urology, Saarland University, 66421 Homburg, Saar, Germany.ORCID 0000-0002-0873-8128
Matthias SaarDepartment of Urology, Saarland University, 66421 Homburg, Saar, Germany.
Saarland University · DE

Funding

European Association of Urology EAU RF Seeding Grant 2018
6 · The paper itself

Abstract

Radical prostatectomy in oligometastatic prostate cancer is a matter of intense debate. Besides avoiding local complications, it is hypothesized that primary tumor resection may result in better oncological outcomes. The aim of our study was to analyze the effect of primary tumor resection on disease progression in an orthotopic prostate cancer mouse model. First, the optimal time point for primary tumor resection, when metastases have already occurred, but the primary tumor is still resectable, was determined as 8 weeks after inoculation of 5 × 10

Indexed as

cytoreductive primary tumor removalmetastasesoligometastatic prostate cancerorthotopic mouse modelradical prostatectomy

Identifiers

PMID35159004
PMCPMC8833735
OpenAlexW4210711999

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.