Evidence map›Paper›PMID 35159064›Full record

ArticleCancers2022

Kristin S Inman, Yi Liu, Michele L Scotti Buzhardt, Michael Leitges, Murli Krishna, Howard C Crawford, Alan P Fields, Nicole R Murray

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Autophagy and the pancreas: Healthy and disease states.Frontiers in cell and developmental biology · 2024
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Kristin S InmanDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.
Yi LiuDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.
Michele L Scotti BuzhardtDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-4696-1611
Michael LeitgesDepartment of BioMedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1M 2V7, Canada.ORCID 0000-0003-4203-6995
Murli KrishnaDepartment of Pathology/Lab Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
Howard C CrawfordDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.
Alan P FieldsDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.
Nicole R MurrayDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.
Mayo Clinic in Florida · USMemorial University of Newfoundland · CANational Institute of Environmental Health Sciences · USWinnMed · US

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3M
Three-Dimensional Organoid Cultures to Investigate 3q26 Driver Functions in Multiple Lung Cancer Cells of OriginR01CA081436 · NCI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI FIELDS, ALAN P. · 1999 to 2022
$9.9M
Role of PKC iota in metaplasia and initiation of pancreatic cancerR01CA140290 · NCI · MAYO CLINIC JACKSONVILLE · PI MURRAY, NICOLE R · 2011 to 2015
$1.6M
NCI NIH HHS CA140290NCI NIH HHS P30 CA015083NCI NIH HHS R01 CA081436
6 · The paper itself

Abstract

Protein kinase C iota (PKCι) functions as a bonafide human oncogene in lung and ovarian cancer and is required for

Indexed as

autophagyimmune cell infiltrationpancreatic cancerprotein kinase C iotatumor progression

Identifiers

PMID35159064
PMCPMC8834021
OpenAlexW4210413671

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.