Evidence map›Paper›PMID 35159165›Full record

ArticleCells2022

Neuron-Microglia Contact-Dependent Mechanisms Attenuate Methamphetamine-Induced Microglia Reactivity and Enhance Neuronal Plasticity.

Joana Bravo, Inês Ribeiro, Ana Filipa Terceiro, Elva B Andrade, Camila Cabral Portugal, Igor M Lopes, Maria M Azevedo, Mafalda Sousa, Cátia D F Lopes, Andrea C Lobo and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Role of Microglia in Psychostimulant Addiction.Current neuropharmacology · 2023
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Joana BravoAddiction Biology, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto (UP), 4200-135 Porto, Portugal.
Inês RibeiroLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0002-4923-3599
Ana Filipa TerceiroAddiction Biology, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto (UP), 4200-135 Porto, Portugal.
Elva B AndradeIBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto (UP), 4200-135 Porto, Portugal.ORCID 0000-0002-1941-580X
Camila Cabral PortugalIBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto (UP), 4200-135 Porto, Portugal.ORCID 0000-0002-1093-6545
Igor M LopesIBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto (UP), 4200-135 Porto, Portugal.ORCID 0000-0001-9047-2711
Maria M AzevedoIBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto (UP), 4200-135 Porto, Portugal.
Mafalda SousaIBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto (UP), 4200-135 Porto, Portugal.ORCID 0000-0003-2238-1070
Cátia D F LopesMolecular Bionics Group-Institute for Bioengineering of Catalonia (IBEC), 08028 Barcelona, Spain.
Andrea C LoboAddiction Biology, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto (UP), 4200-135 Porto, Portugal.
Teresa CanedoAddiction Biology, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto (UP), 4200-135 Porto, Portugal.ORCID 0000-0002-4000-153X
João Bettencourt RelvasIBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto (UP), 4200-135 Porto, Portugal.
Teresa SummavielleAddiction Biology, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto (UP), 4200-135 Porto, Portugal.ORCID 0000-0003-2548-6281
Universidade do Porto · PTInstitute for Bioengineering of Catalonia · ESUniversity of Minho · PT

Funding

Fundação para a Ciência e Tecnologia PTDC/SAU-TOX/30647/2017Fundação para a Ciência e Tecnologia UIDB/04293/2020
6 · The paper itself

Abstract

Exposure to methamphetamine (Meth) has been classically associated with damage to neuronal terminals. However, it is now becoming clear that addiction may also result from the interplay between glial cells and neurons. Recently, we demonstrated that binge Meth administration promotes microgliosis and microglia pro-inflammation via astrocytic glutamate release in a TNF/IP

Indexed as

MethamphetamineMicrogliaNeurogliaNeuronal PlasticityNeuronsMethamphetamineCD200contact-dependentmethamphetamineneuron-to-microglianeuroprotectionPSD95

Identifiers

PMID35159165
PMCPMC8834016
OpenAlexW4205567332

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.