Evidence map›Paper›PMID 35159297›Full record

ArticleCells2022

Plasma Small Extracellular Vesicles with Complement Alterations in

Sonia Bellini, Claudia Saraceno, Luisa Benussi, Rosanna Squitti, Sara Cimini, Martina Ricci, Laura Canafoglia, Cinzia Coppola, Gianfranco Puoti, Clarissa Ferrari and 8 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkers.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  4. Article
  5. Plasma Small Extracellular Vesicle Cathepsin D Dysregulation inInternational journal of molecular sciences · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Sonia BelliniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-6162-252X
Claudia SaracenoMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0001-8618-4282
Luisa BenussiMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0003-2836-8141
Rosanna SquittiMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Sara CiminiUnit of Neurology V-Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Martina RicciUnit of Neurology V-Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Laura CanafogliaIntegrated Diagnostics for Epilepsy, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0002-5385-761X
Cinzia CoppolaDepartment of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", 80131 Naples, Italy.ORCID 0000-0002-1125-6779
Gianfranco PuotiDepartment of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", 80131 Naples, Italy.
Clarissa FerrariService of Statistics, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Antonio LongobardiMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-8292-6434
Roland NicsanuMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-6621-8729
Marta LombardiCNR Institute of Neuroscience, 20129 Milan, Italy.
Giulia D'ArrigoCNR Institute of Neuroscience, 20129 Milan, Italy.ORCID 0000-0003-3984-8888
Claudia VerderioCNR Institute of Neuroscience, 20129 Milan, Italy.
Giuliano BinettiMAC-Memory Clinic and Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Giacomina RossiUnit of Neurology V-Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0001-6680-2725
Roberta GhidoniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-7691-1957
Centro San Giovanni di Dio Fatebenefratelli · ITFondazione IRCCS Istituto Neurologico Carlo Besta · ITNeuroscience Institute · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

Ministero della Salute RF-2016-02361492Ministero della Salute Ricerca Corrente
6 · The paper itself

Abstract

Cutting-edge research suggests endosomal/immune dysregulation in

Indexed as

C9orf72 ProteinComplement System ProteinsExtracellular VesiclesFrontotemporal DementiaFrontotemporal Lobar DegenerationProgranulinsHumansIntercellular Signaling Peptides and ProteinsRetrospective StudiesC9orf72 ProteinC9orf72 protein, humanComplement System ProteinsGRN protein, humanIntercellular Signaling Peptides and ProteinsProgranulinsbiomarkersC9orf72complement proteinsendo-lysosomal pathwayextracellular vesiclesfrontotemporal lobar degenerationGRNnanoparticle tracking analysisneuronal ceroid lipofuscinosisplasma

Identifiers

PMID35159297
PMCPMC8834212
OpenAlexW4210304906

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.