Evidence map›Paper›PMID 35163206›Full record

ReviewInternational journal of molecular sciences2022

Undifferentiated Sarcomatoid Carcinoma of the Pancreas: From Histology and Molecular Pathology to Precision Oncology.

Anastasios Gkountakos, Michele Simbolo, Elena Bariani, Aldo Scarpa, Claudio Luchini

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anastasios GkountakosARC-NET Applied Research on Cancer Center, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-9001-0293
Michele SimboloDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-0866-4499
Elena BarianiDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, 37134 Verona, Italy.
Aldo ScarpaARC-NET Applied Research on Cancer Center, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-1678-739X
Claudio LuchiniARC-NET Applied Research on Cancer Center, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-4901-4908
University of Verona · IT

Funding

Associazione Italiana Ricerca Cancro AIRC IG n. 26343Fondazione Cariverona 203885/2017Fondazione Italiana Malattie Pancreas J38D19000690001
6 · The paper itself

Abstract

Undifferentiated sarcomatoid carcinoma of the pancreas (SCP) is a rare and aggressive subtype of pancreatic cancer. Histologically, SCP is a poorly differentiated tumor characterized by the lack of glandular differentiation and the presence of mesenchymal-like, spindle-shaped tumor cells. Due to its rarity, only sporadic cases have been reported, while its molecular characterization has not been sufficiently described. Surgical resection with curative intent is the gold-standard of SCP management, but this strategy is possible only in a small proportion of cases due to SCP early metastasization. Although SCP is generally associated with a poor prognosis, some clinical cases amenable to surgical resection and followed by adjuvant chemotherapy have demonstrated a remarkably long survival. Preliminary molecular insights on the SCP molecular landscape have demonstrated the recurrent presence of

Indexed as

Chemotherapy, AdjuvantHumansImmunotherapyMedical OncologyMutationPancreasPancreatic NeoplasmsPrecision MedicineProto-Oncogene Proteins p21(ras)SarcomaTumor Suppressor Protein p53KRAS protein, humanProto-Oncogene Proteins p21(ras)Tumor Suppressor Protein p53EMTmesenchymalpancreatic ductal adenocarcinomaPDACsarcomatoid

Identifiers

PMID35163206
PMCPMC8835772
OpenAlexW4210376697

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.