Evidence map›Paper›PMID 35163483›Full record

ArticleInternational journal of molecular sciences2022

Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver.

Giovan N Cholico, Rance Nault, Tim R Zacharewski

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Functional genomic analysis of non-canonical DNA regulatory elements of the aryl hydrocarbon receptor.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice.Toxicological sciences : an official journal of the Society of Toxicology · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Giovan N CholicoBiochemistry & Molecular Biology, Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-3582-8698
Rance NaultBiochemistry & Molecular Biology, Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-6822-4962
Tim R ZacharewskiBiochemistry & Molecular Biology, Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA.
Michigan State University · US

Funding

VOLATILE ORGANIC CONTAMINANTS--QUANTIFYING THEIR MOVEMENT IN THE UNSATURATED ZONEP42ES004911 · NIEHS · MICHIGAN STATE UNIVERSITY · PI Brian P. Johnson · 1989 to 2026
$64.9M
MULTIDISCIPLINARY TRAINING IN ENVIRONMENTAL TOXICOLOGYT32ES007255 · NIEHS · MICHIGAN STATE UNIVERSITY · PI JOHN J LAPRES · 1989 to 2026
$9.3M
AhR-dependent Pkm2 regulation in NAFLD progressionR01ES029541 · NIEHS · MICHIGAN STATE UNIVERSITY · PI ZACHAREWSKI, TIMOTHY R. · 2019 to 2023
$1.9M
National Institute of Environmental Health Sciences, Superfund Research Program P42ES004911NIEHS NIH HHS P42 ES004911NIEHS NIH HHS R01 ES029541NIEHS NIH HHS R01ES029541NIEHS NIH HHS T32 ES007255NIEHS NIH HHS T32ES007255
6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known for mediating the toxicity of 2,3,7,8-tetrachlorodibenzo-

Indexed as

Chromatin Immunoprecipitation SequencingGenomeAnimalsBase SequenceCOUP Transcription FactorsDatabases, GeneticGene Expression ProfilingGene Expression RegulationHepatocyte Nuclear Factor 4LiverMaleMiceMice, Inbred C57BLNucleotide MotifsPolychlorinated DibenzodioxinsProtein BindingCOUP Transcription FactorsHepatocyte Nuclear Factor 4Polychlorinated DibenzodioxinsReceptors, Aryl Hydrocarbon2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)aryl hydrocarbon receptor (AhR)ChIPseqCOUP-transcription factor II (COUP-TFII)hepatocyte nuclear factor 4 alpha (HNF4α)livertoxicogenomics

Identifiers

PMID35163483
PMCPMC8836158
OpenAlexW4220655218

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.