Evidence map›Paper›PMID 35163785›Full record

ArticleInternational journal of molecular sciences2022

Cytoprotective Activity of Polyamines Is Associated with the Alternative Splicing of

Yulia A Gladilina, Lylia Bey, Abdullah Hilal, Ekaterina V Neborak, Varvara G Blinova, Dmitry D Zhdanov

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yulia A GladilinaInstitute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.
Lylia BeyDepartment of Biochemistry, Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya St. 6, 117198 Moscow, Russia.
Abdullah HilalInstitute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.
Ekaterina V NeborakDepartment of Biochemistry, Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya St. 6, 117198 Moscow, Russia.
Varvara G BlinovaInstitute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.
Dmitry D ZhdanovInstitute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.ORCID 0000-0003-4753-7588
Institute of Biomedical Chemistry · RUPeoples' Friendship University of Russia · RU

Funding

The Ministry of Education and Science of the Russian Federation RF00121X0004
6 · The paper itself

Abstract

Physiological polyamines are ubiquitous polycations with pleiotropic biochemical activities, including regulation of gene expression and cell proliferation as well as modulation of cell signaling. They can also decrease DNA damage and promote cell survival. In the present study, we demonstrated that polyamines have cytoprotective effects on normal human CD4

Indexed as

Alternative SplicingCD4-Positive T-LymphocytesCell SurvivalCisplatinDNA DamageDoxorubicinHumansIrinotecanJurkat CellsK562 CellsPolyaminesRad51 RecombinaseRNA PrecursorsCisplatinDoxorubicinIrinotecanPolyaminesRAD51 protein, humanRad51 RecombinaseRNA Precursorsalternative splicingapoptosiscytoprotectionDNA damagepolyamines

Identifiers

PMID35163785
PMCPMC8837172
OpenAlexW4210930643

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.