Evidence map›Paper›PMID 35164060›Full record

ReviewMolecules (Basel, Switzerland)2022

Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications.

Tomasz Kowalczyk, Anna Merecz-Sadowska, Laurent Picot, Irena Brčić Karačonji, Joanna Wieczfinska, Tomasz Śliwiński, Przemysław Sitarek

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Review
  3. Harnessing endophytes and Multi-Omics for sustainable Colchicine biosynthesis.World journal of microbiology & biotechnology · 2026
    Review
  4. Review
  5. Review
  6. Establishment of Shoot Cultures ofInternational journal of molecular sciences · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Cell-derived nanomaterials for biomedical applications.Science and technology of advanced materials · 2024
    Review
  19. Plant Tissue Culture: Industrial Relevance and Future Directions.Advances in biochemical engineering/biotechnology · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tomasz KowalczykDepartment of Molecular Biotechnology and Genetics, University of Lodz, 90-237 Lodz, Poland.ORCID 0000-0002-4559-5015
Anna Merecz-SadowskaDepartment of Economic Informatics, University of Lodz, 90-214 Lodz, Poland.ORCID 0000-0001-9987-4573
Laurent PicotLittoral Environnement et Sociétés UMRi CNRS 7266 LIENSs, La Rochelle Université, 17042 La Rochelle, France.ORCID 0000-0003-4656-3557
Irena Brčić KaračonjiAnalytical Toxicology and Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia.ORCID 0000-0002-1151-8839
Joanna WieczfinskaDepartment of Immunopathology, Medical University of Lodz, 90-752 Lodz, Poland.ORCID 0000-0002-8830-1507
Tomasz ŚliwińskiLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.ORCID 0000-0001-8385-7744
Przemysław SitarekDepartment of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland.ORCID 0000-0001-5495-3550

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, there has been a considerable increase in interest in the use of transgenic plants as sources of valuable secondary metabolites or recombinant proteins. This has been facilitated by the advent of genetic engineering technology with the possibility for direct modification of the expression of genes related to the biosynthesis of biologically active compounds. A wide range of research projects have yielded a number of efficient plant systems that produce specific secondary metabolites or recombinant proteins. Furthermore, the use of bioreactors allows production to be increased to industrial scales, which can quickly and cheaply deliver large amounts of material in a short time. The resulting plant production systems can function as small factories, and many of them that are targeted at a specific operation have been patented. This review paper summarizes the key research in the last ten years regarding the use of transgenic plants as small, green biofactories for the bioreactor-based production of secondary metabolites and recombinant proteins; it simultaneously examines the production of metabolites and recombinant proteins on an industrial scale and presents the current state of available patents in the field.

Indexed as

BioreactorsBiotechnologyIndustryCell Culture TechniquesPlants, Genetically ModifiedRecombinant ProteinsRecombinant Proteinsbioreactorsgenetic manipulationpatentsrecombinant proteinssecondary metabolitestransgenic plant cultures

Identifiers

PMID35164060
PMCPMC8840042

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.