Evidence map›Paper›PMID 35164658›Full record

ArticleBioengineered2022

Effects of urolithin A on osteoclast differentiation induced by receptor activator of nuclear factor-κB ligand via bone morphogenic protein 2.

Zhe Wang, Guobin Qi, Zhuokai Li, Xu Cui, Shengyang Guo, Yueqi Zhang, Pan Cai, Xiuhui Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Zhe WangDepartment of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, China.
Guobin QiDepartment of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhuokai LiDepartment of Orthopedics, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Xu CuiDepartment of Orthopedics, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Shengyang GuoDepartment of Orthopedics, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Yueqi ZhangDepartment of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, China.
Pan CaiDepartment of Orthopedics, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Xiuhui WangDepartment of Orthopedics, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Shanghai University of Medicine and Health Sciences · CNFudan University · CNSun Yat-sen University · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urolithin A (UA) is an intestinal microbial metabolite derived from ellagitannins and a promising agent for treating osteoarthritis. However, its effects on osteoporosis are unclear. This study explored the effects of urolithin A (UA) on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclasts and its underlying molecular mechanisms. RANKL treatment significantly increased tartrate-resistant acid phosphatase (TRACP) or osteoclast marker levels (

Indexed as

Bone Morphogenetic Protein 2Bone ResorptionCoumarinsOsteoporosisAnimalsCell DifferentiationMiceNFATC Transcription FactorsNF-kappa BOsteoclastsRANK LigandRAW 264.7 Cells3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-oneBmp2 protein, mouseBone Morphogenetic Protein 2CoumarinsNFATC Transcription FactorsNF-kappa BRANK LigandBMP2osteoclastRANKLRAW264.7 cellstranscriptome sequencingurolithin A

Identifiers

PMID35164658
PMCPMC8974137
OpenAlexW4212889797

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.