Evidence map›Paper›PMID 35165191›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome.

Jing Wang, Henning Fröhlich, Felipe Bodaleo Torres, Rangel Leal Silva, Gernot Poschet, Amit Agarwal, Gudrun A Rappold

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 73 citations in OpenAlex.

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  13. Cellular fibronectin exacerbates α-synuclein aggregation via integrin alpha4beta1 mediated PARP1 and SCD elevation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jing WangDepartment of Human Molecular Genetics, Institute of Human Genetics, Heidelberg University Hospital, D-69120 Heidelberg, Germany.ORCID 0000-0003-3419-3990
Henning FröhlichDepartment of Human Molecular Genetics, Institute of Human Genetics, Heidelberg University Hospital, D-69120 Heidelberg, Germany.
Felipe Bodaleo TorresChica and Heinz Schaller Research Group, Institute for Anatomy and Cell Biology, D-69120 Heidelberg, Germany.
Rangel Leal SilvaChica and Heinz Schaller Research Group, Institute for Anatomy and Cell Biology, D-69120 Heidelberg, Germany.ORCID 0000-0002-1322-7808
Gernot PoschetMetabolomics Core Technology Platform, Centre for Organismal Studies, University of Heidelberg, D-69120 Heidelberg, Germany.ORCID 0000-0002-5344-0865
Amit AgarwalChica and Heinz Schaller Research Group, Institute for Anatomy and Cell Biology, D-69120 Heidelberg, Germany.
Gudrun A RappoldDepartment of Human Molecular Genetics, Institute of Human Genetics, Heidelberg University Hospital, D-69120 Heidelberg, Germany; gudrun.rappold@med.uni-heidelberg.de.
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FOXP1 syndrome caused by haploinsufficiency of the forkhead box protein P1 (FOXP1) gene is a neurodevelopmental disorder that manifests motor dysfunction, intellectual disability, autism, and language impairment. In this study, we used a

Indexed as

AnimalsAutism Spectrum DisorderAutistic DisorderCognitionDisease Models, AnimalForkhead Transcription FactorsHaploinsufficiencyIntellectual DisabilityMiceMice, Inbred C57BLMitochondriaMotor ActivityMotor DisordersNeurodevelopmental DisordersNeurogenesisOxidative StressForkhead Transcription FactorsFoxp1 protein, mouseRepressor ProteinsASDcognitive and motor impairmentFOXP1 syndromemitochondrial defectROS

Identifiers

PMID35165191
PMCPMC8872729
OpenAlexW4220792642

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.