ArticleThe journal of nutrition, health & aging2022
A Cross-Sectional Study of Association between Plasma Selenium Levels and the Prevalence of Osteoarthritis: Data from the Xiangya Osteoarthritis Study.
Article in The journal of nutrition, health & aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Associations between Dietary Selenium Intake and Risk of Incident Arthritis: Based on UK Biobank WebQ Assessment (2009-2012).Biological trace element research · 2026Article
- Circulating Essential Trace Element and Mineral Levels in Female Patients with Knee or Concomitant Knee and Hip Osteoarthritis.Biological trace element research · 2026Article
- Elemental Influence: The Emerging Role of Zinc, Copper, and Selenium in Osteoarthritis.Nutrients · 2025Review
- Mapping the role of macro and micronutrients in bone mineral density: a comprehensive Mendelian randomization study.European journal of nutrition · 2025Article
- Nutritional interventions for osteoarthritis: targeting the metabolism-inflammation-oxidative stress axis-clinical evidence and translational practice.Frontiers in nutrition · 2025Review
- Bidirectional association identified between synovitis and knee and hand osteoarthritis: a general population-based study.The Lancet regional health. Western Pacific · 2024Article
- Novel insights into the role of metabolic disorder in osteoarthritis.Frontiers in endocrinology · 2024Review
- Injectable hydrogel with selenium nanoparticles delivery for sustained glutathione peroxidase activation and enhanced osteoarthritis therapeutics.Materials today. Bio · 2023Article
- A national cross-sectional analysis of selenium intake and risk of osteoarthritis: NHANES 2003-2016.Frontiers in public health · 2022Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSelenium plays an indispensable role in antioxidant and antiinflammation processes. Oxidative stress and inflammation have been hypothesized to be involved in the pathogenesis of cartilage degeneration. We sought to examine the association between plasma selenium levels and the prevalence of radiographic osteoarthritis (ROA).
designA population-based cross-sectional study. SETTING AND
participantsIndividuals aged ≥ 50 years were retrieved from the Xiangya Osteoarthritis (XO) Study, a community-based study conducted among the residents of the rural areas of China.
methodsPlasma selenium concentration was measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry. ROA was defined as Kellgren/Lawrence score ≥ 2 in at least one knee, hip or hand joint. The association between plasma selenium levels and ROA was evaluated by applying logistic and spline regression.
resultsA total of 1,032 subjects (women: 52.5%; mean age: 63.1 years; ROA prevalence: 45.4%) were included. Compared with the highest tertile, the odds ratios (ORs) for ROA were 1.24 (95% confidence interval [CI]: 0.91 to 1.68) and 1.77 (95% CI: 1.31 to 2.40) in the middle and lowest tertile of plasma selenium, respectively (P for trend<0.05). The results were not changed materially with adjustment of potential confounders. In addition, subjects who had lower plasma selenium levels exhibited a higher prevalence of ROA in a dose-response relationship manner (P=0.005).
conclusionThis study suggests that subjects with lower levels of plasma selenium exhibited a higher prevalence of ROA in a dose-response relationship manner. However, additional studies are still needed to verify the potential causal relationship.
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