Evidence map›Paper›PMID 35166587›Full record

ArticleRadiology2022

Myocardial Injury Pattern at MRI in COVID-19 Vaccine-Associated Myocarditis.

Matteo Fronza, Paaladinesh Thavendiranathan, Victor Chan, Gauri Rani Karur, Jacob A Udell, Rachel M Wald, Rachel Hong, Kate Hanneman

Open access · greenAbstract read
In one paragraph

Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 5 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 5 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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  6. Field strength dependence, physiologic correlates, and prognostic significance of ventricular blood pool T2 mapping on cardiovascular magnetic resonance imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
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  12. Abnormal coronary vascular response in patients with long COVID syndrome - a case-control study using oxygenation-sensitive cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Matteo FronzaFrom the Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W., R.H., K.H.) and Division of Cardiology (P.T., J.A.U., R.M.W.), Toronto General Hospital, Peter Munk Cardiac Centre, University Health Network (UHN), University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; and Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W.) and Cardiovascular Division (J.A.U.), Women's College Hospital, University of Toronto, Toronto, Canada.ORCID 0000-0002-8127-9503
Paaladinesh ThavendiranathanFrom the Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W., R.H., K.H.) and Division of Cardiology (P.T., J.A.U., R.M.W.), Toronto General Hospital, Peter Munk Cardiac Centre, University Health Network (UHN), University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; and Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W.) and Cardiovascular Division (J.A.U.), Women's College Hospital, University of Toronto, Toronto, Canada.ORCID 0000-0002-6497-1098
Victor ChanFrom the Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W., R.H., K.H.) and Division of Cardiology (P.T., J.A.U., R.M.W.), Toronto General Hospital, Peter Munk Cardiac Centre, University Health Network (UHN), University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; and Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W.) and Cardiovascular Division (J.A.U.), Women's College Hospital, University of Toronto, Toronto, Canada.ORCID 0000-0002-1232-063X
Gauri Rani KarurFrom the Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W., R.H., K.H.) and Division of Cardiology (P.T., J.A.U., R.M.W.), Toronto General Hospital, Peter Munk Cardiac Centre, University Health Network (UHN), University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; and Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W.) and Cardiovascular Division (J.A.U.), Women's College Hospital, University of Toronto, Toronto, Canada.
Jacob A UdellFrom the Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W., R.H., K.H.) and Division of Cardiology (P.T., J.A.U., R.M.W.), Toronto General Hospital, Peter Munk Cardiac Centre, University Health Network (UHN), University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; and Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W.) and Cardiovascular Division (J.A.U.), Women's College Hospital, University of Toronto, Toronto, Canada.ORCID 0000-0001-7402-9584
Rachel M WaldFrom the Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W., R.H., K.H.) and Division of Cardiology (P.T., J.A.U., R.M.W.), Toronto General Hospital, Peter Munk Cardiac Centre, University Health Network (UHN), University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; and Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W.) and Cardiovascular Division (J.A.U.), Women's College Hospital, University of Toronto, Toronto, Canada.ORCID 0000-0002-2373-6438
Rachel HongFrom the Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W., R.H., K.H.) and Division of Cardiology (P.T., J.A.U., R.M.W.), Toronto General Hospital, Peter Munk Cardiac Centre, University Health Network (UHN), University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; and Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W.) and Cardiovascular Division (J.A.U.), Women's College Hospital, University of Toronto, Toronto, Canada.
Kate HannemanFrom the Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W., R.H., K.H.) and Division of Cardiology (P.T., J.A.U., R.M.W.), Toronto General Hospital, Peter Munk Cardiac Centre, University Health Network (UHN), University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; and Department of Medical Imaging (M.F., P.T., V.C., G.R.K., R.M.W.) and Cardiovascular Division (J.A.U.), Women's College Hospital, University of Toronto, Toronto, Canada.ORCID 0000-0002-3077-2218
University Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background There are limited data on the pattern and severity of myocardial injury in patients with COVID-19 vaccination-associated myocarditis. Purpose To describe myocardial injury following COVID-19 vaccination and to compare these findings to other causes of myocarditis. Materials and Methods In this retrospective cohort study, consecutive adult patients with myocarditis with at least one T1-based and at least one T2-based abnormality at cardiac MRI performed at a tertiary referral hospital from December 2019 to November 2021 were included. Patients were classified into one of three groups: myocarditis following COVID-19 vaccination, myocarditis following COVID-19 illness, and other myocarditis not associated with COVID-19 vaccination or illness. Results Of the 92 included patients, 21 (23%) had myocarditis following COVID-19 vaccination (mean age, 31 years ± 14 [SD]; 17 men; messenger RNA-1273 in 12 [57%] and BNT162b2 in nine [43%]). Ten of 92 (11%) patients had myocarditis following COVID-19 illness (mean age, 51 years ± 14; three men) and 61 of 92 (66%) patients had other myocarditis (mean age, 44 years ± 18; 36 men). MRI findings in the 21 patients with vaccine-associated myocarditis included late gadolinium enhancement (LGE) in 17 patients (81%) and left ventricular dysfunction in six (29%). Compared with other causes of myocarditis, patients with vaccine-associated myocarditis had a higher left ventricular ejection fraction and less extensive LGE, even after controlling for age, sex, and time from symptom onset to MRI. The most frequent location of LGE in all groups was subepicardial at the basal inferolateral wall, although septal involvement was less common in vaccine-associated myocarditis. At short-term follow-up (median, 22 days [IQR, 7-48 days]), all patients with vaccine-associated myocarditis were asymptomatic with no adverse events. Conclusion Cardiac MRI demonstrated a similar pattern of myocardial injury in vaccine-associated myocarditis compared with other causes, although abnormalities were less severe, with less frequent septal involvement and no adverse events over the short-term follow-up. © RSNA, 2022

Indexed as

COVID-19COVID-19 VaccinesMyocarditis2019-nCoV Vaccine mRNA-1273AdolescentAdultBNT162 VaccineContrast MediaFemaleGadoliniumHumansMagnetic Resonance Imaging, CineMaleMiddle AgedMyocardiumRetrospective Studies2019-nCoV Vaccine mRNA-1273BNT162 VaccineContrast MediaCOVID-19 VaccinesGadolinium

Identifiers

PMID35166587
PMCPMC8856022
OpenAlexW4212940536

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.