SynthesisPain medicine (Malden, Mass.)2022
Mood and Anxiety Symptoms in Persons Taking Prescription Opioids: A Systematic Review with Meta-Analyses of Longitudinal Studies.
Synthesis in Pain medicine (Malden, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identifying transdiagnostically relevant risk and protective factors for internalizing psychopathology: An umbrella review of longitudinal meta-analyses.Journal of psychiatric research · 2023Pooled it
- Effects of Buprenorphine/Naloxone and Methadone on Depressive Symptoms in People with Prescription Opioid Use Disorder: A Pragmatic Randomised Controlled Trial.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Trial
- Real-World Assessment of Healthcare Resource Utilization-Defined Manic and Depressive Events Among Patients with Bipolar I Disorder Treated with Cariprazine Versus Aripiprazole.Advances in therapy · 2026Article
- Prescription opioid use and 12-month depression trajectories.Psychiatry research · 2026Article
- Insights from deep learning models on new-onset anxiety in patients following bariatric metabolic surgery.Journal of affective disorders reports · 2026Article
- Article
- Effect of a brief art therapy intervention on anxiety and pain in emergency department patients: a randomized open-label trial.International journal of emergency medicine · 2026Article
- Criterion validity and divergent risk profiles of long-term opioid therapy across medicare and medicaid.PloS one · 2026Article
- Association Between Opioid Dosage Tapering and Opioid Overdose Among Long-Term Higher-Dose Opioid Users.AJPM focus · 2025Article
- Relationship Between Opioid Use, Depression, and Quality of Life Among Persons With HIV at End of Life.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Effect of prescribing and deprescribing oxycodone on pain and function in a mouse model of osteoarthritis: impact of polypharmacy and sex on response.bioRxiv : the preprint server for biology · 2025Article
- Association Between Different Patterns of Opioid and Benzodiazepine Use and Risks of Emergency Department Visits and Hospitalizations: A Retrospective Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Opioid Therapy in Chronic Pain: Assessment of Clinical Outcomes and Relationships With Endocrine Biomarkers.European journal of pain (London, England) · 2025Article
- Article
- Psychosocial correlates of depression and anxiety among treatment-seeking individuals with opioid dependence: a cross-sectional study.Frontiers in psychiatry · 2025Article
- Incubation of social deficit during morphine abstinence in male mice using a novel unbiased and automatized method.Frontiers in behavioral neuroscience · 2025Article
- Factors predicting outcomes from chronic pain management interventions.BMJ medicine · 2025Review
- Pharmacological Strategies to Decrease Long-Term Prescription Opioid Use: A Systematic Review.Journal of clinical medicine · 2024Review
- Oral fentanyl consumption and withdrawal impairs fear extinction learning and enhances basolateral amygdala principal neuron excitatory-inhibitory balance in male and female mice.Addiction neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review evidence from longitudinal studies on the association between prescription opioid use and common mood and anxiety symptoms.
designWe conducted a systematic review and meta-analysis according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
methodsWe searched PubMed, Embase, and PsycINFO for search terms related to opioids AND (depression OR bipolar OR anxiety OR post-traumatic stress disorder [PTSD]). Findings were summarized narratively, and random-effects meta-analyses were used to pool effect sizes.
resultsWe identified 10,290 records and found 10 articles that met our inclusion criteria. Incidence studies showed that people who used prescription opioids had an elevated risk of any mood outcome (adjusted effect size [aES] = 1.80 [95% confidence interval = 1.40-2.30]) and of an anxiety outcome (aES = 1.40 [1.20-1.80]) compared with those who did not use prescription opioids. Associations with depression were small and not significant after adjustment for potential confounders (aES = 1.18 [0.98-1.41]). However, some studies reported an increased risk of depressive symptoms after increased (aES = 1.58 [1.30-1.93]) or prolonged opioid use (aES = 1.49 [1.19-1.86]).
conclusionsMental health should be considered when opioids are prescribed because some patients could be vulnerable to adverse mental health outcomes.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.