Evidence map›Paper›PMID 35169883›Full record

ArticleParasitology research2022

Functionalized 1,2,3-triazolium salts as potential agents against visceral leishmaniasis.

Ayla das Chagas Almeida, Raíssa Soares Meinel, Yasmim Lopes Leal, Thiago P Silva, Nícolas Glanzmann, Débora Vasconcelos Costa Mendonça, Luísa Perin, Edézio Ferreira Cunha-Júnior, Eduardo A F Coelho, Rossana C N Melo and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Parasitology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Research Advances on the Bioactivity of 1,2,3-Triazolium Salts.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ayla das Chagas AlmeidaNúcleo de Pesquisas Em Parasitologia, Departamento de Parasitologia, Microbiologia e Imunologia, I.C.B., Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais, Brazil.
Raíssa Soares MeinelSINTBIOMOL, Departamento de Química, I.C.E., Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais, Brazil.
Yasmim Lopes LealSINTBIOMOL, Departamento de Química, I.C.E., Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais, Brazil.
Thiago P SilvaLaboratório de Biologia Celular, Departamento de Biologia, Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais, Brazil.
Nícolas GlanzmannSINTBIOMOL, Departamento de Química, I.C.E., Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais, Brazil.
Débora Vasconcelos Costa MendonçaPrograma de Pós-Graduação Em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Luísa PerinPrograma de Pós-Graduação Em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Edézio Ferreira Cunha-JúniorLaboratório de Imunoparasitologia, Unidade Integrada de Pesquisa Em Produtos Bioativos e Biociências, Universidade Federal Do Rio de Janeiro, Campus UFRJ-Macaé, Macaé, Brazil.
Eduardo A F CoelhoPrograma de Pós-Graduação Em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Rossana C N MeloLaboratório de Biologia Celular, Departamento de Biologia, Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais, Brazil.
Adilson David da SilvaSINTBIOMOL, Departamento de Química, I.C.E., Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais, Brazil.
Elaine Soares CoimbraNúcleo de Pesquisas Em Parasitologia, Departamento de Parasitologia, Microbiologia e Imunologia, I.C.B., Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais, Brazil. elaine.coimbra@ufjf.edu.br.
Universidade Federal de Juiz de Fora · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visceral leishmaniasis (VL) is the most severe clinical form of leishmaniasis, being fatal if untreated. In search of a more effective treatment for VL, one of the main strategies is the development and screening of new antileishmanial compounds. Here, we reported the synthesis of seven new acetyl functionalized 1,2,3-triazolium salts, together with four 1,2,3-triazole precursors, and investigated their effect against different strains of L. infantum from dogs and humans. The 1,2,3-triazolium salts exhibited better activity than the 1,2,3-triazole derivatives with IC

Indexed as

Antiprotozoal AgentsLeishmania infantumLeishmaniasis, VisceralAnimalsDogsMiceMice, Inbred BALB CSaltsTriazolesAntiprotozoal AgentsSaltsTriazoles1,2,3-Triazolium saltsAutophagy processIn vitro activityLeishmania infantumMitochondrial alterationMurine visceral leishmaniasis

Identifiers

PMID35169883
OpenAlexW4213101771

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.