Evidence map›Paper›PMID 35169901›Full record

ArticlePflugers Archiv : European journal of physiology2022

Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes.

David H Vandorpe, Alicia Rivera, Markus Ganter, Selasi Dankwa, Jay G Wohlgemuth, Jeffrey S Dlott, L Michael Snyder, Carlo Brugnara, Manoj Duraisingh, Seth L Alper

Abstract read
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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

David H VandorpeDivision of Nephrology, Beth Israel Deaconess Medical Center, 99 Brookline Ave., Boston, MA, 02215, USA.
Alicia RiveraDivision of Nephrology, Beth Israel Deaconess Medical Center, 99 Brookline Ave., Boston, MA, 02215, USA.
Markus GanterDepartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, 02115, USA.
Selasi DankwaDepartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, 02115, USA.
Jay G WohlgemuthQuest Diagnostics, Secaucus, NJ, 07094, USA.
Jeffrey S DlottQuest Diagnostics, Secaucus, NJ, 07094, USA.
L Michael SnyderQuest Diagnostics, Secaucus, NJ, 07094, USA.
Carlo BrugnaraDepartment of Laboratory Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Manoj DuraisinghDepartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, 02115, USA.
Seth L AlperDivision of Nephrology, Beth Israel Deaconess Medical Center, 99 Brookline Ave., Boston, MA, 02215, USA. salper@bidmc.harvard.edu.ORCID 0000-0002-6228-2512
Beth Israel Deaconess Medical Center · USHarvard University · USQuest Diagnostics (United States) · USBoston Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paracrine ATP release by erythrocytes has been shown to regulate endothelial cell function via purinergic signaling, and this erythoid-endothelial signaling network is pathologically dysregulated in sickle cell disease. We tested the role of extracellular ATP-mediated purinergic signaling in the activation of Psickle, the mechanosensitive Ca

Indexed as

Anemia, Sickle CellReticulocytesAdenosine TriphosphateApyraseCationsCells, CulturedErythrocytesHumansHydrogen-Ion ConcentrationHypoxiaProbenecidSuraminAdenosine TriphosphateApyraseCationsProbenecidSuraminApyraseEctonucleotidaseP2 receptorsPannexin-1Sickle cell disease

Identifiers

PMID35169901
OpenAlexW4212781502

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.