ArticlePaediatric and perinatal epidemiology2022
Adverse motor outcome after paediatric ischaemic stroke: A nationwide cohort study.
Article in Paediatric and perinatal epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Motor Function Profiling and Its Impact on Health-Related Quality of Life in Childhood Stroke Survivors.Archives of rehabilitation research and clinical translation · 2026Article
- Unseen struggles: a narrative review of psychosocial and family outcomes following pediatric stroke.Frontiers in psychology · 2026Review
- Maternal Overweight and Obesity and Risk of Perinatal Ischemic Stroke: A Nationwide Cohort Study.Neurology · 2025Article
- From brain injury to classroom: cognitive and academic outcomes after pediatric stroke. A narrative review.Frontiers in neurology · 2025Review
- Brain Maturation as a Fundamental Factor in Immune-Neurovascular Interactions in Stroke.Translational stroke research · 2024Review
- A Review of Current Perspectives on Motoric Insufficiency Rehabilitation following Pediatric Stroke.Healthcare (Basel, Switzerland) · 2024Review
- Neuromotor Rehabilitation Interventions After Pediatric Stroke: A Focused Review.Seminars in pediatric neurology · 2022Review
- Adverse motor outcome after paediatric ischaemic stroke: A nationwide cohort study.Paediatric and perinatal epidemiology · 2022Article
- Association of Perinatal and Childhood Ischemic Stroke With Attention-Deficit/Hyperactivity Disorder.JAMA network open · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVarious frequencies of adverse motor outcomes (cerebral palsy and hemiplegia) after paediatric ischaemic stroke have been reported. Few reports on the risks of adverse motor outcomes in nationwide cohorts and contributing risk factors are available.
objectivesTo assess risk of adverse motor outcome and potential risk factors thereof after paediatric ischaemic stroke in a nationwide cohort.
methodsThis nationwide matched cohort study identified 877 children <18 years of age diagnosed with ischaemic stroke through the Swedish national health registers from 1997 to 2016. These children, exposed to ischaemic stroke, alive 1 week after stroke, were matched for age, sex and county of residence with 10 unexposed children. Using Cox regression, we estimated the risk of adverse motor outcomes in children with stroke compared to that in unexposed children. Logistic regression was applied to compare the characteristics of children with and without adverse motor outcomes after stroke.
resultsOut of the 877 children with ischaemic stroke, 280 (31.9%) suffered adverse motor outcomes compared with 21 (0.2%) of the 8770 unexposed: adjusted hazard ratio (aHR) 167.78 (95% confidence interval (CI) 107.58, 261.66). There were no differences between risk estimates of adverse motor outcome according to age at stroke: perinatal stroke (aHR 124.11, 95% CI 30.45, 505.84) and childhood stroke (aHR 182.37, 95% CI 113.65, 292.64). An association between adverse motor outcome and childhood stroke aOR 1.56 (95% CI 1.05, 2.31) was found when analysing only children with ischaemic stroke. No associations were found between adverse motor outcome and sex, gestational age or parental age at birth.
conclusionsThe risk of adverse motor outcome is substantial after paediatric ischaemic stroke, especially childhood stroke, confirming results of previous smaller studies. This study found no associations between sex, gestational age or parental age and adverse motor outcome after paediatric ischaemic stroke.
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