Evidence map›Paper›PMID 35175840›Full record

ReviewCirculation research2022

Coronary Arterial Function and Disease in Women With No Obstructive Coronary Arteries.

Harmony R Reynolds, C Noel Bairey Merz, Colin Berry, Rohit Samuel, Jacqueline Saw, Nathaniel R Smilowitz, Ana Carolina do A H de Souza, Robert Sykes, Viviany R Taqueti, Janet Wei

Open access · bronzeAbstract readReview
In one paragraph

Review in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
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  10. Guideline for Chronic Coronary Syndrome - 2025.Arquivos brasileiros de cardiologia · 2025
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  15. Societal, occupational, and economic considerations for women with (M)INOCA: a narrative review.International journal of occupational medicine and environmental health · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Harmony R ReynoldsSarah Ross Soter Center for Women's Cardiovascular Research, Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, NY (H.R.R., N.R.S.).ORCID 0000-0003-0284-0655
C Noel Bairey MerzBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (C.N.B.M., J.W.).ORCID 0000-0002-9933-5155
Colin BerryBritish Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (C.B.).ORCID 0000-0002-4547-8636
Rohit SamuelVancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada (R.S., J.S.).
Jacqueline SawVancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada (R.S., J.S.).ORCID 0000-0002-7027-984X
Nathaniel R SmilowitzSarah Ross Soter Center for Women's Cardiovascular Research, Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, NY (H.R.R., N.R.S.).
Ana Carolina do A H de SouzaCardiovascular Imaging Program, Departments of Radiology and Medicine (Cardiology), Brigham and Women's Hospital, Harvard Medical School, Boston, MA (A.C.d.A.H.d.S., V.R.T.).
Robert SykesWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (C.B., R.S.).ORCID 0000-0003-1010-5474
Viviany R TaquetiCardiovascular Imaging Program, Departments of Radiology and Medicine (Cardiology), Brigham and Women's Hospital, Harvard Medical School, Boston, MA (A.C.d.A.H.d.S., V.R.T.).ORCID 0000-0002-0136-3781
Janet WeiBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (C.N.B.M., J.W.).ORCID 0000-0002-1311-618X
Brigham and Women's Hospital · USCedars-Sinai Smidt Heart Institute · USGolden Jubilee National Hospital · GBNew York University · USVancouver General Hospital · CA

Funding

The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)U54AG065141 · NIA · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2020 to 2024
$8.7M
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL146158 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL · 2019 to 2023
$3.7M
Whole-Heart Myocardial Blood Flow Quantification Using MRIR01HL124649 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO · 2015 to 2018
$3.3M
Myocardial Steatosis in Women with Coronary Microvascular Dysfunction: Defining the Pathway to Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL153500 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI WEI, JANET · 2021 to 2025
$3.2M
Hematopoietic Stem Cell engraftment in the injured nicheR01HL162649 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI LUCAS, DANIEL · 2022 to 2024
$1.6M
Extension to Coronary Flow Reserve to Assess Hidden Risk: Focus on Women, Heart Failure, and InflammationK23HL135438 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAQUETI, VIVIANY R · 2017 to 2021
$1.1M
Magnetic Resonance Imaging for Global Atherosclerosis Risk AssessmentK23HL125941 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI WEI, JANET · 2016 to 2020
$985k
Mechanisms of Coronary Microvascular DiseaseK23HL150315 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SMILOWITZ, NATHANIEL ROSSO · 2020 to 2024
$948k
British Heart Foundation FS/17/26/32744British Heart Foundation PG/18/52-33892British Heart Foundation PG/18/52/33892British Heart Foundation RE/18/6/34217Medical Research Council MR/S018905/1Medical Research Council MR/SO18905/1NHLBI NIH HHS K23 HL125941NHLBI NIH HHS K23 HL135438NHLBI NIH HHS K23 HL150315NHLBI NIH HHS R01 HL124649NHLBI NIH HHS R01 HL146158NHLBI NIH HHS R01 HL153500NHLBI NIH HHS R01 HL162649NIA NIH HHS U54 AG065141
6 · The paper itself

Abstract

Ischemic heart disease (IHD) is the leading cause of mortality in women. While traditional cardiovascular risk factors play an important role in the development of IHD in women, women may experience sex-specific IHD risk factors and pathophysiology, and thus female-specific risk stratification is needed for IHD prevention, diagnosis, and treatment. Emerging data from the past 2 decades have significantly improved the understanding of IHD in women, including mechanisms of ischemia with no obstructive coronary arteries and myocardial infarction with no obstructive coronary arteries. Despite this progress, sex differences in IHD outcomes persist, particularly in young women. This review highlights the contemporary understanding of coronary arterial function and disease in women with no obstructive coronary arteries, including coronary anatomy and physiology, mechanisms of ischemia with no obstructive coronary arteries and myocardial infarction with no obstructive coronary arteries, noninvasive and invasive diagnostic strategies, and management of IHD.

Indexed as

Adrenergic beta-AntagonistsCoronary AngiographyCoronary Artery DiseaseCoronary CirculationCoronary VesselsFemaleHumansRisk Reduction BehaviorAdrenergic beta-Antagonistscoronary diseasecoronary vesselsmyocardial infarctionrisk factorssex characteristics

Identifiers

PMID35175840
PMCPMC8911308
OpenAlexW4212986363

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.