Evidence map›Paper›PMID 35177595›Full record

ArticleNature communications2022

ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.

Christophe Royer, Elizabeth Sandham, Elizabeth Slee, Falk Schneider, Christoffer B Lagerholm, Jonathan Godwin, Nisha Veits, Holly Hathrell, Felix Zhou, Karolis Leonavicius and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 3 countries.

Christophe RoyerDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK. christophe.royer@dpag.ox.ac.uk.ORCID http://orcid.org/0000-0002-9882-7676
Elizabeth SandhamDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK.
Elizabeth SleeLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Falk SchneiderMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-0502-9139
Christoffer B LagerholmWolfson Imaging Centre Oxford, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Jonathan GodwinDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK.
Nisha VeitsDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK.ORCID http://orcid.org/0000-0003-2851-4591
Holly HathrellDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK.
Felix ZhouLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Karolis LeonaviciusDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK.
Jemma GarrattDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK.ORCID http://orcid.org/0000-0003-0863-2021
Tanaya NarendraDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK.ORCID http://orcid.org/0000-0002-7695-5781
Anna VincentOxford Fertility, Institute of Reproductive Sciences, Oxford Business Park North, Oxford, OX4 2HW, UK.
Celine JonesNuffield Department of Women's and Reproductive Health, University of Oxford, Level 3, Women's Centre, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK.
Tim ChildNuffield Department of Women's and Reproductive Health, University of Oxford, Level 3, Women's Centre, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK.
Kevin CowardNuffield Department of Women's and Reproductive Health, University of Oxford, Level 3, Women's Centre, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK.
Chris GrahamNuffield Department of Women's and Reproductive Health, University of Oxford, Level 3, Women's Centre, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK.
Marco FritzscheKennedy Institute for Rheumatology, University of Oxford, Oxford, OX3 7LF, UK.ORCID http://orcid.org/0000-0002-8712-7471
Xin LuLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.ORCID http://orcid.org/0000-0002-6587-1152
Shankar SrinivasDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK. shankar.srinivas@dpag.ox.ac.uk.ORCID http://orcid.org/0000-0001-5726-7791
University of Oxford · GBJohn Radcliffe Hospital · GBOxford Fertility · GBUniversity of Southern California · USVilnius University · LT

Funding

Medical Research Council MC_UU_12009Medical Research Council MC_UU_12010Wellcome TrustWellcome Trust 212343/Z/18/ZWellcome Trust WT 0009773Wellcome Trust WT104924A1AWellcome Trust (Wellcome) 103788/Z/14/Z
6 · The paper itself

Abstract

During development, pseudostratified epithelia undergo large scale morphogenetic events associated with increased mechanical stress. Using a variety of genetic and imaging approaches, we uncover that in the mouse E6.5 epiblast, where apical tension is highest, ASPP2 safeguards tissue integrity. It achieves this by preventing the most apical daughter cells from delaminating apically following division events. In this context, ASPP2 maintains the integrity and organisation of the filamentous actin cytoskeleton at apical junctions. ASPP2 is also essential during gastrulation in the primitive streak, in somites and in the head fold region, suggesting that it is required across a wide range of pseudostratified epithelia during morphogenetic events that are accompanied by intense tissue remodelling. Finally, our study also suggests that the interaction between ASPP2 and PP1 is essential to the tumour suppressor function of ASPP2, which may be particularly relevant in the context of tissues that are subject to increased mechanical stress.

Indexed as

MorphogenesisActin CytoskeletonAnimalsApoptosis Regulatory ProteinsCaco-2 CellsCell PolarityDogsEmbryo Culture TechniquesEmbryo, MammalianEpitheliumFemaleGastrulationGerm LayersHumansMadin Darby Canine Kidney CellsMiceApoptosis Regulatory Proteinsneuropeptide Y4 receptorReceptors, Neuropeptide YTP53BP2 protein, humanTrp53bp2 protein, mouseTumor Suppressor Proteins

Identifiers

PMID35177595
PMCPMC8854694
OpenAlexW4213132288

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.