ArticleScientific reports2022
The spectrum of comorbidities at the initial diagnosis of heart failure a case control study.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- A Systematic Review of Codelists to Identify Chronic Bronchitis and Emphysema in Routine Electronic Healthcare Record Data and Derivation of a Standardized Codelist for Future Research.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- Refining a hybrid music therapy intervention for chronic obstructive pulmonary disease and heart failure: a single arm pilot study.BMC complementary medicine and therapies · 2025Trial
- The Importance of Setting Comparable Index Dates Between Cohorts in TriNetX.JACC. Advances · 2026Article
- Real-World Cardiovascular Research Using the German IQVIA Disease Analyzer Database: Methods, Evidence, and Limitations (2000-2025).Journal of cardiovascular development and disease · 2026Review
- Sex and Gender Aspects in New-Onset Heart Failure Prognosis: A Review of Recent Advances.Current heart failure reports · 2025Review
- A novel treatment score (QUAD score) to promote treatment optimization in heart failure with a reduced ejection fraction.ESC heart failure · 2025Article
- European Journal of Heart Failure consensus statement. Heart failure pharmacotherapy for patients with heart failure with reduced ejection fraction and concomitant atrial fibrillation: Review of evidence and call to action.European journal of heart failure · 2025Review
- Health-related quality of life and associated factors among individuals with heart failure attending public hospitals in Nekemte town, Western Oromia, Ethiopia: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- The association of hemorrhoids with the incidence of heart failure: a nationwide cohort study.Annals of translational medicine · 2025Article
- Disease Network-Based Approaches to Study Comorbidity in Heart Failure: Current State and Future Perspectives.Current heart failure reports · 2024Review
- Impact of the COVID-19 pandemic on hospital-based heart failure care in New South Wales, Australia: a linked data cohort study.BMC health services research · 2024Article
- Exploring the Spectrum of Comorbidities Associated with Primary Aldosteronism: Insights from a Large Real-World Case-Control Study.Biomedicines · 2024Article
- Prevalence and incidence of heart failure in type 2 diabetes patients: results from a nationwide prospective cohort-the DIABET-IC study.Cardiovascular diabetology · 2024Observational
- Effect of dapagliflozin on uric acid in patients with chronic heart failure and hyperuricemia.World journal of clinical cases · 2024Article
- Race, Social Determinants of Health, and Comorbidity Patterns Among Participants with Heart Failure in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.Discover social science and health · 2024Article
- Computational modeling of heart failure in microgravity transitions.Frontiers in physiology · 2024Article
- Heart Failure Prevalence Rates and Its Association with Other Cardiovascular Diseases and Chronic Kidney Disease: SIMETAP-HF Study.Journal of clinical medicine · 2023Article
- Review
- Chronic Obstructive Pulmonary Disease in Elderly Patients with Acute and Advanced Heart Failure: Palliative Care Needs-Analysis of the EPICTER Study.Journal of clinical medicine · 2022Article
- Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prognosis of heart failure (HF) patients is determined to a decisive extent by comorbidities. The present study investigates the association between a broad spectrum of diseases and the occurrence of HF in a large collective of outpatients. This retrospective case control study assessed the prevalence of 37 cardiac and extracardiac diseases in patients with an initial diagnosis of heart failure (ICD-10: I50) in 1,274 general practices in Germany between January 2005 and December 2019. The study is based on the Disease Analyzer database (IQVIA), which contains drug prescriptions, diagnoses, and basic medical and demographic data. Patients with and without heart failure were matched by sex, age, and index year. Hazard regression models were conducted to evaluate the association between different disease entities and heart failure. The present study included 162,246 patients with heart failure and 162,246 patients without heart failure. Mean age [SD] was 73.7 [12.1] years; 52.6% were women. Out of 37 predefined diagnoses, 36 were more prevalent in HF patients. The highest prevalence was primary hypertension (63.4% in HF patients vs. 53.3% in controls, p < 0.001) followed by lipid metabolism disorders (34.6% in HF patients vs. 29.1% in HF patients p < 0.001) and diabetes mellitus type II (32.2% in HF patients vs. 25.2% in controls, p < 0.001). In the regression analysis, 19 diseases were significantly associated with heart failure. Non-cardiovascular diagnoses strongly associated with HF were obesity (HR = 1.46), chronic bronchitis and COPD (HR = 1.41), gout (HR: 1.41), and chronic kidney disease (HR = 1.27). In the present study, we identified a variety of cardiac and extracardiac diseases associated with heart failure. Our data underscore the immense importance of comorbidities, even as early as at the stage of initial diagnosis of heart failure.
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