Evidence map›Paper›PMID 35179319›Full record

ArticleCancer communications (London, England)2022

Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression.

Jie Chen, Kang Li, Jianwen Chen, Xiaochen Wang, Rongsong Ling, Maosheng Cheng, Zhi Chen, Fangfang Chen, Qianting He, Shuai Li and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer communications (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 197 citations in OpenAlex.

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  7. RNA modifications in cancer and their detection: a review.Japanese journal of clinical oncology · 2026
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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Jie ChenDepartment of Oral and Maxillofacial Surgery, Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.
Kang LiDepartment of Oral and Maxillofacial Surgery, Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.
Jianwen ChenDepartment of Oral and Maxillofacial Surgery, Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.
Xiaochen WangDepartment of Oral and Maxillofacial Surgery, Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.
Rongsong LingInstitute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, 518000, P. R. China.
Maosheng ChengDepartment of Oral and Maxillofacial Surgery, Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.
Zhi ChenDepartment of Oral and Maxillofacial Surgery, Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.
Fangfang ChenDepartment of Oral and Maxillofacial Surgery, Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.
Qianting HeDepartment of Oral and Maxillofacial Surgery, Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.
Shuai LiDepartment of Oral and Maxillofacial Surgery, Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.
Caihua ZhangDepartment of Oral and Maxillofacial Surgery, Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.
Yizhou JiangInstitute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, 518000, P. R. China.
Qianming ChenSchool of Stomatology, Cancer Center, and Key Laboratory of Oral Biomedical Research of Zhejiang Province, Clinical Research Center of Oral Diseases of Zhejiang Province, Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, P. R. China.
Anxun WangDepartment of Oral and Maxillofacial Surgery, Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.
Demeng ChenDepartment of Oral and Maxillofacial Surgery, Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.ORCID 0000-0001-7230-2495
Sun Yat-sen University · CNShenzhen University · CNStomatology Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer cells selectively promote the translation of oncogenic transcripts to stimulate cancer progression. Although growing evidence has revealed that tRNA modifications and related genes participate in this process, their roles in head and neck squamous cell carcinoma (HNSCC) remain largely uncharacterized. Here, we sought to investigate the function and mechanisms of the transfer RNA (tRNA) N7-methylguanosine (m

methodsCell lost-of-function and gain-of-function assays, xenograft models, conditional knockout and knockin mouse models were used to study the physiological functions of tRNA m

resultsThe tRNA m

conclusionsThe tRNA m

Indexed as

Head and Neck NeoplasmsProto-Oncogene Proteins c-aktAnimalsCarcinogenesisGTP-Binding ProteinsGuanosineHumansMammalsMethyltransferasesMicePhosphatidylinositol 3-KinasesRNA, TransferSquamous Cell Carcinoma of Head and NeckTOR Serine-Threonine KinasesTumor Microenvironment8-methylguanosineGTP-Binding ProteinsGuanosineMethyltransferasesMETTL1 protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, TransferTOR Serine-Threonine KinasesWDR4 protein, humanhead and neck squamous cell carcinomam7G modificationmetastasisMETTL1microenvironmentPI3K/AKT/mTOR signalingscRNA-seqtRNAWDR4

Identifiers

PMID35179319
PMCPMC8923133
OpenAlexW4213081200

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.