ArticleJournal of Alzheimer's disease : JAD2022
Sex-Specific Patterns of Body Mass Index Relationship with White Matter Connectivity.
Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Novel brain biomarkers of obesity in young adult women based on statistical measurements of white matter tracts.PloS one · 2025Article
- Relationships between abdominal adipose tissue and neuroinflammation with diffusion basis spectrum imaging in midlife obesity.Obesity (Silver Spring, Md.) · 2025Article
- Identifying obesity and dementia risk: body adiposity and neural connectivity in cognitively normal, mid-life adults.NPJ dementia · 2025Article
- Interactive Relations of Body Mass Index, Cardiorespiratory Fitness, and Sex to Cognitive Function in Older Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Effects of Vascular Risk Factors on the White Matter Network Architecture of the Brain.Neuroscience bulletin · 2024Article
- The Interaction Effects of Sex, Age, APOE and Common Health Risk Factors on Human Brain Functions.medRxiv : the preprint server for health sciences · 2024Article
- Edge Density Imaging Identifies White Matter Biomarkers of Late-Life Obesity and Cognition.Aging and disease · 2024Article
- Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals.Aging and disease · 2024Article
- A Cross-Sectional Study of Protein Changes Associated with Dementia in Non-Obese Weight Matched Women with and without Polycystic Ovary Syndrome.International journal of molecular sciences · 2024Article
- A Cross-Sectional Study of Alzheimer-Related Proteins in Women with Polycystic Ovary Syndrome.International journal of molecular sciences · 2024Article
- Body mass index and two-year change of in vivo Alzheimer's disease pathologies in cognitively normal older adults.Alzheimer's research & therapy · 2023Article
- Sex Differences in the Associations of Obesity with Tau, Amyloid PET, and Cognitive Outcomes in Preclinical Alzheimer's Disease: Cross-Sectional A4 Study.Journal of Alzheimer's disease : JAD · 2023Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObesity is an increasingly recognized modifiable risk factor for Alzheimer's disease (AD). Increased body mass index (BMI) is related to distinct changes in white matter (WM) fiber density and connectivity.
objectiveWe investigated whether sex differentially affects the relationship between BMI and WM structural connectivity.
methodsA cross-sectional sample of 231 cognitively normal participants were enrolled from the Knight Alzheimer Disease Research Center. Connectome analyses were done with diffusion data reconstructed using q-space diffeomorphic reconstruction to obtain the spin distribution function and tracts were selected using a deterministic fiber tracking algorithm.
resultsWe identified an inverse relationship between higher BMI and lower connectivity in the associational fibers of the temporal lobe in overweight and obese men. Normal to overweight women showed a significant positive association between BMI and connectivity in a wide array of WM fibers, an association that reversed in obese and morbidly obese women. Interaction analyses revealed that with increasing BMI, women showed higher WM connectivity in the bilateral frontoparietal and parahippocampal parts of the cingulum, while men showed lower connectivity in right sided corticostriatal and corticopontine tracts. Subgroup analyses demonstrated comparable results in participants with and without positron emission tomography or cerebrospinal fluid evidence of brain amyloidosis, indicating that the relationship between BMI and structural connectivity in men and women is independent of AD biomarker status.
conclusionBMI influences structural connectivity of WM differently in men and women across BMI categories and this relationship does not vary as a function of preclinical AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.