SynthesisGeneral hospital psychiatry
Mortality from coronavirus disease 2019 (Covid-19) in patients with schizophrenia: A systematic review, meta-analysis and meta-regression.
Synthesis in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Rheumatoid arthritis and COVID-19 outcomes: a systematic review and Meta-analysis.BMC rheumatology · 2024Pooled it
- Inflammatory bowel disease and COVID-19 outcomes: a meta-analysis.Scientific reports · 2022Pooled it
- Health service utilization by people with psychosis during Peru's mental health reform and the COVID-19 pandemic: a population-based study.Lancet regional health. Americas · 2026Article
- Cancer-related mortality among individuals with schizophrenia: systematic review and meta-analysis of cohort studies.BJPsych open · 2026Review
- Evolution of Paris' public hospital psychiatrics outpatients from 2019 to 2023: a retrospective cohort study.European archives of psychiatry and clinical neuroscience · 2026Article
- Characterizing Infectious Disease Mortality in Severe Mental Illness: A Retrospective Matched Cohort Study.Schizophrenia bulletin · 2026Article
- Severe Outcomes and Length of Stay Among People With Schizophrenia Hospitalized for COVID-19: A Population-Based Retrospective Cohort Study.Schizophrenia bulletin · 2026Article
- Health inequalities among people with disabilities: an umbrella review and evidence synthesis.EClinicalMedicine · 2026Review
- Modeling the Role of Baseline Risk and Additional Study-Level Covariates in Meta-Analysis of Treatment Effects.Statistics in medicine · 2025Article
- Long term outcomes after COVID-19 in patients with schizophrenia: a historical cohort study in a health maintenance organization.Social psychiatry and psychiatric epidemiology · 2025Article
- Dual inflammation in schizophrenia infected with COVID-19: Impact on cognitive function.Brain, behavior, & immunity - health · 2025Article
- Reduced SARS-CoV-2 vaccine-specific antibody response associated with high clozapine doses in schizophrenia spectrum disorders.Brain, behavior, & immunity - health · 2025Article
- Vaccine protection against COVID-19-related mortality in patients with schizophrenia: a retrospective cohort study.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Observational
- Associations Between Psychosocial Influence, Positive Thinking, and Vaccine Attitudes in Patients with Schizophrenia During the COVID-19 Pandemic.Psychology research and behavior management · 2025Article
- Effectiveness of AstraZeneca vaccine against SARS-CoV-2 (ChAdox1-S) in reducing in-hospital mortality in individuals with COVID-19 and schizophrenia: A retrospective cohort study.Human vaccines & immunotherapeutics · 2024Article
- Severe mental illness and infectious disease mortality: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- A Canadian Call for Addressing Physical Health in Specialized Mental Health Settings.Healthcare policy = Politiques de sante · 2024Article
- COVID-19-associated mortality in individuals with serious mental disorders in Sweden during the first two years of the pandemic- a population-based register study.BMC psychiatry · 2024Article
- Racial differences in attenuated psychotic symptoms during the COVID-19 pandemic.Early intervention in psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSchizophrenia has been associated with patients' poor quality of life, disability, and hospitalization. As of today, evidence that highlights the association between schizophrenia and coronavirus disease (Covid-19) outcomes remains unclear. This study sought to analyze whether patients with pre-existing schizophrenia are at higher risk for Covid-19 mortality.
methodsUsing specific keywords, we comprehensively searched PubMed, Scopus, OVID, and Cochrane Library sources until November 15th, 2021. All published studies on schizophrenia and Covid-19 were collected. We used Review Manager 5.4 and Comprehensive Meta-Analysis 3 software to conduct statistical analysis.
resultsThere were 10 studies with 263,207 Covid-19 patients included in the analysis. Evaluation of the data gathered yielded an association between schizophrenia and increased mortality from Covid-19 (RR 2.22; 95%CI: 1.54-3.20, p < 0.00001, I
conclusionsThis study proposes that patients with pre-existing schizophrenia are at risk of developing higher Covid-19 mortality. Patients with schizophrenia need special attention and should be prioritized to receive the SARS-CoV-2 vaccine. REGISTRATION DETAILS: CRD42021293997.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.