Evidence map›Paper›PMID 35185477›Full record

ReviewFrontiers in neural circuits2021

Müller Glia in Retinal Development: From Specification to Circuit Integration.

Joshua M Tworig, Marla B Feller

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neural circuits, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joshua M TworigDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Marla B FellerDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
University of California, Berkeley · US

Funding

UC Berkeley Vision Science COREP30EY003176 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Xiaohua Gong · 1985 to 2026
$16.4M
The Function of Neural Activity in Developing RetinaR01EY013528 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Marla Feller · 2002 to 2026
$8.1M
Development of direction selectivity in the retinaR01EY019498 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Marla Feller · 2009 to 2026
$6.6M
NEI NIH HHS P30 EY003176NEI NIH HHS R01 EY013528NEI NIH HHS R01 EY019498
6 · The paper itself

Abstract

Müller glia of the retina share many features with astroglia located throughout the brain including maintenance of homeostasis, modulation of neurotransmitter spillover, and robust response to injury. Here we present the molecular factors and signaling events that govern Müller glial specification, patterning, and differentiation. Next, we discuss the various roles of Müller glia in retinal development, which include maintaining retinal organization and integrity as well as promoting neuronal survival, synaptogenesis, and phagocytosis of debris. Finally, we review the mechanisms by which Müller glia integrate into retinal circuits and actively participate in neuronal signaling during development.

Indexed as

NeurogliaRetinaAstrocytesNeurogenesisPhagocytosismorphogenesisneuronal-glial signalingNotchsynaptogenesistranscription factor

Identifiers

PMID35185477
PMCPMC8856507
OpenAlexW4213365970

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.