ArticleFrontiers in immunology2022
Antigen-Presenting Cells and T Cells Interact in a Specific Area of the Intestinal Mucosa Defined by the Ccl25-Ccr9 Axis in Medaka.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Immune regulation of neuronal stem cells in the medaka retina.Development (Cambridge, England) · 2026Article
- Teleost intestinal microfold cells: identification, characterization, and mucosal antigen sampling in olive flounder (Marine life science & technology · 2026Article
- Role of mucosal chemokines in the development of tissue-resident CD4Frontiers in immunology · 2026Review
- Maxing Shigan Decoction Alleviates Lung Heat Syndrome by Inhibiting α4β7-Mediated γδT17 Cell Migration Across the Gut-Lung-Nasal Axis.Journal of inflammation research · 2025Article
- Developing neural network diagnostic models and potential drugs based on novel identified immune-related biomarkers for celiac disease.Human genomics · 2023Article
- Immunohistochemistry of the Gut-Associated Lymphoid Tissue (GALT) in African Bonytongue (International journal of molecular sciences · 2023Article
- Maturation of the medaka immune system depends on reciprocal interactions between the microbiota and the intestinal tract.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organized intestinal mucosal immune response appears to be restricted to tetrapods. In teleost fish, there is no evidence for the existence of a particular intestinal region that facilitates the interaction of antigen-presenting cells (APCs) and T cells, such as secondary lymphoid organs. Indeed, despite their importance in the defense against pathogens, the location and manner of APC-T cell interaction within the fish gut is unknown. Here, using non-invasive live imaging of newly developed transgenic reporter lines, we addressed the spatial organization and behavior of APCs and T cells in the intestine of medaka fish both during homeostasis and inflammation. We report that Ccr9a
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