Evidence map›Paper›PMID 35189057›Full record

ArticleACS nano2022

Visualization of Partial Exocytotic Content Release and Chemical Transport into Nanovesicles in Cells.

Tho Duc Khanh Nguyen, Lisa Mellander, Alicia Lork, Aurélien Thomen, Mai Philipsen, Michael E Kurczy, Nhu T N Phan, Andrew G Ewing

Abstract read
In one paragraph

Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Exocytosis of Nanoparticles: A Comprehensive Review.Nanomaterials (Basel, Switzerland) · 2023
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tho Duc Khanh NguyenDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden.
Lisa MellanderDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden.
Alicia LorkDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden.
Aurélien ThomenDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden.
Mai PhilipsenDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg SE-412 96, Sweden.
Michael E KurczyDMPK, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg S-431 83, Sweden.ORCID 0000-0001-6579-9691
Nhu T N PhanDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden.ORCID 0000-0002-3576-0494
Andrew G EwingDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden.ORCID 0000-0002-2084-0133

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For decades, "all-or-none" and "kiss-and-run" were thought to be the only major exocytotic release modes in cell-to-cell communication, while the significance of partial release has not yet been widely recognized and accepted owing to the lack of direct evidence for exocytotic partial release. Correlative imaging with transmission electron microscopy and NanoSIMS imaging and a dual stable isotope labeling approach was used to study the cargo status of vesicles before and after exocytosis; demonstrating a measurable loss of transmitter in individual vesicles following stimulation due to partial release. Model secretory cells were incubated with

Indexed as

DopamineIodineBiological TransportCatecholaminesExocytosisCatecholaminesDopamineIodineexocytosisfraction of neurotransmitter releasenanoimagingnanosimspartial release

Identifiers

PMID35189057
PMCPMC8945366

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.