SynthesisEnvironmental research2022
Does protracted radon exposure play a role in the development of dementia?
Synthesis in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Exposure to radon and ambient particle radioactivity during pregnancy and adverse maternal, fetal and perinatal outcomes: The current literature and potential mechanisms.Environmental research · 2024Pooled it
- Exposure to Ionizing Radiation and Risk of Dementia: A Systematic Review and Meta-Analysis.Radiation research · 2023Pooled it
- Assessing historical residential radon exposure using a glass-based surface trap method in low radon level areas: a pilot study.Journal of radiological protection : official journal of the Society for Radiological Protection · 2026Article
- The unique effects of chronic exposure to ambient fine particulate matter and indoor radon on subcortical brain morphology in youth.Neurotoxicology · 2026Article
- Chronic radon exposure is associated with developmental alterations to neural and behavioral indices of cognitive control.NeuroImage · 2025Article
- AOP-helpFinder 3.0: from text mining to network visualization of key event relationships, and knowledge integration from multiple sources.Bioinformatics (Oxford, England) · 2025Article
- Radon Exposure and Gestational Diabetes.JAMA network open · 2025Observational
- Neurotoxic effects of home radon exposure on oscillatory dynamics serving attentional orienting in children and adolescents.NeuroImage · 2024Article
- Effects of chronic home radon exposure on cognitive, behavioral, and mental health in developing children and adolescents.Frontiers in psychology · 2024Article
- Smoking Modifies the Association Between Radon Exposure and Incident Ischemic Stroke: The REGARDS Study.Stroke · 2023Article
- DNA methylome profiling in occupational radon exposure miners using an Illumina Infinium Methylation EPIC BeadChip.Toxicology research · 2023Article
- Chronic Home Radon Exposure Is Associated with Higher Inflammatory Biomarker Concentrations in Children and Adolescents.International journal of environmental research and public health · 2022Article
- Criterion Validity of Radon Test Values Reported by a Commercial Laboratory versus the Environmental Protection Agency.International journal of environmental research and public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Radon is a ubiquitous radioactive gas that decays into a series of solid radioactive decay products. Radon, and its decay products, enter the human body primarily through inhalation and can be delivered to various tissues including the brain through systemic circulation. It can also reach the brain by neuronal pathways via the olfactory system. While ionizing radiation has been suggested as a risk factor of dementia for decades, studies exploring the possible role of radon exposure in the development of Alzheimer's Diseases (AD) and other dementias are sparse. We systematically reviewed the literature and found several lines of evidence suggesting that radon decay products (RDPs) disproportionally deposit in the brain of AD patients with selective accumulation within the protein fractions. Ecologic study findings also indicate a significant positive correlation between geographic-level radon distribution and AD mortality in the US. Additionally, pathologic studies of radon shed light on the potential pathways of radon decay product induced proinflammation and oxidative stress that may result in the development of dementia. In summary, there are plausible underlying biological mechanisms linking radon exposure to the risk of dementia. Since randomized clinical trials on radon exposure are not feasible, well-designed individual-level epidemiologic studies are urgently needed to elucidate the possible association between radon (i.e., RDPs) exposure and the onset of dementia.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.