SynthesisNeuroscience and biobehavioral reviews2022
Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects.
Synthesis in Neuroscience and biobehavioral reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- The Impact of Adverse Childhood Experiences on Cognitive Control Across the Lifespan: A Systematic Review and Meta-analysis of Prospective Studies.Trauma, violence & abuse · 2025Pooled it
- The effects of childhood adversity: Two specific neural patterns.Neuroscience and biobehavioral reviews · 2025Pooled it
- Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- Adversity and adolescent brain development: differential associations with grey and white matter across two longitudinal cohorts.bioRxiv : the preprint server for biology · 2026Article
- Depression and aging: insights from brain age prediction models.Psychological medicine · 2026Article
- Associations between early-life adversity, coping strategies, and adult mental health, brain, and cognition.Scientific reports · 2026Article
- Persistent structural alteration of the extended limbic system in adolescents with childhood maltreatment.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Bibliometric analysis of childhood adversity and anxiety disorders: Trends, hotspots and international collaboration.Global mental health (Cambridge, England) · 2026Article
- The biological burden of conflict across populations worldwide.Clinical and translational medicine · 2026Article
- Associations between early life adversity and the development of gray matter macrostructure and microstructure.Psychological medicine · 2025Article
- Gray matter correlates of childhood maltreatment lack replicability in a multi-cohort brain-wide association study.Nature communications · 2025Article
- Role of the Central Cholinergic Nervous System in Motor and Non-Motor Symptoms of Parkinson's Disease.Current neuropharmacology · 2025Review
- Relationships between serotonin 1A receptor DNA methylation, self-reported history of childhood abuse and gray matter volume in major depression.Journal of affective disorders · 2024Article
- Childhood adversity, stress reactivity, and structural brain measures in stress-related/neurodevelopmental disorders, and their comorbidity: A large transdiagnostic cross-sectional study.Human brain mapping · 2024Article
- The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research.Molecular psychiatry · 2024Review
- The association between adverse childhood experiences and alterations in brain volume and cortical thickness in adults with alcohol use disorder.Addiction biology · 2024Article
- Early Life Adversity Predicts Reduced Hippocampal Volume in the Adolescent Brain Cognitive Development Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2024Article
- Longitudinal variation in resilient psychosocial functioning is associated with ongoing cortical myelination and functional reorganization during adolescence.Nature communications · 2024Article
- Cortical growth from infancy to adolescence in preterm and term-born children.Brain : a journal of neurology · 2024Article
- Interplay of early negative life events, development of orbitofrontal cortical thickness and depression in young adulthood.JCPP advances · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Early life adversities (ELAs) are associated with an increased risk of psychopathology, with studies suggesting a relation to structural brain alterations. Given the recently growing evidence of ELA effects on brain structure, an updated summary is highly warranted. Therefore, anatomical likelihood estimation was used to conduct a coordinate-based meta-analysis of gray matter volume (GMV) alterations associated with ELAs, including sub-analyses for different age groups and maltreatment as specific ELA-type. The analyses uncovered a convergence of pooled ELA-effects on GMV in the right hippocampus and amygdala and the left inferior frontal gyrus, age-specific effects for the right amygdala and hippocampus in children and adolescents, and maltreatment-specific effects for the right perigenual anterior cingulate cortex in adults. These results reveal a possible underlying commonality in the impact of adversity and also point to specific age and maltreatment effects. They suggest neural markers of ELAs in regions involved in socio-emotional functioning and stress regulation, with the potential to be used as targets for interventions designed to buffer or reverse harmful ELA-effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.