Evidence map›Paper›PMID 35192844›Full record

ReviewExperimental and molecular pathology2022

Alcohol: basic and translational research; 15th annual Charles Lieber &1st Samuel French satellite symposium.

Manuela G Neuman, Helmut K Seitz, Pamela L Tuma, Natalia A Osna, Carol A Casey, Kusum K Kharbanda, Lawrence B Cohen, Steve D H Malnick, Raghabendra Adhikari, Ramyajit Mitra and 10 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental and molecular pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Fatty Liver Disease-Alcoholic and Non-Alcoholic: Similar but Different.International journal of molecular sciences · 2022
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 4 countries.

Manuela G NeumanIn Vitro Drug Safety and Biotechnology, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada. Electronic address: m_neuman@rogers.com.
Helmut K SeitzCentre of Liver and Alcohol Diseases, Ethianum Clinic, University of Heidelberg, Germany.
Pamela L TumaThe Catholic University of America, Department of Biology, Washington, DC 20064, USA.
Natalia A OsnaVA-Nebraska-Western Iowa Health Care System, Department of Veterans' Affairs, Omaha, NE, and Department of Internal Medicine, Section of Gastroenterology-Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.
Carol A CaseyVA-Nebraska-Western Iowa Health Care System, Department of Veterans' Affairs, Omaha, NE, and Department of Internal Medicine, Section of Gastroenterology-Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.
Kusum K KharbandaVA-Nebraska-Western Iowa Health Care System, Department of Veterans' Affairs, Omaha, NE, and Department of Internal Medicine, Section of Gastroenterology-Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.
Lawrence B CohenDivision of Gastroenterology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Steve D H MalnickDepartment of Internal Medicine C, Kaplan Medical Center, Affiliated Hebrew University, Jerusalem, Israel.
Raghabendra AdhikariThe Catholic University of America, Department of Biology, Washington, DC 20064, USA.
Ramyajit MitraThe Catholic University of America, Department of Biology, Washington, DC 20064, USA.
Raghubendra Singh DagurVA-Nebraska-Western Iowa Health Care System, Department of Veterans' Affairs, Omaha, NE, and Department of Internal Medicine, Section of Gastroenterology-Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.
Murali GanesanVA-Nebraska-Western Iowa Health Care System, Department of Veterans' Affairs, Omaha, NE, and Department of Internal Medicine, Section of Gastroenterology-Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.
Chava SrinivasVA-Nebraska-Western Iowa Health Care System, Department of Veterans' Affairs, Omaha, NE, and Department of Internal Medicine, Section of Gastroenterology-Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.
Arumugam Madan KumarVA-Nebraska-Western Iowa Health Care System, Department of Veterans' Affairs, Omaha, NE, and Department of Internal Medicine, Section of Gastroenterology-Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.
Moses New-AaronVA-Nebraska-Western Iowa Health Care System, Department of Veterans' Affairs, Omaha, NE, and Department of Internal Medicine, Section of Gastroenterology-Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.
Larisa PoluektovaVA-Nebraska-Western Iowa Health Care System, Department of Veterans' Affairs, Omaha, NE, and Department of Internal Medicine, Section of Gastroenterology-Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.
Paul G ThomesVA-Nebraska-Western Iowa Health Care System, Department of Veterans' Affairs, Omaha, NE, and Department of Internal Medicine, Section of Gastroenterology-Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.
Karuna RasineniVA-Nebraska-Western Iowa Health Care System, Department of Veterans' Affairs, Omaha, NE, and Department of Internal Medicine, Section of Gastroenterology-Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.
Mihai OprisIn Vitro Drug Safety and Biotechnology, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada; Family Medicine Clinic CAR, Bucharest, Romania.
Rolf TeschkeDepartment of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Hanau, Academic Teaching Hospital of the Medical Faculty, Goethe University Frankfurt/ Main, Frankfurt/Main, Germany.
University of Nebraska Medical Center · USUniversity of Toronto · CAVA Nebraska Western Iowa Health Care System · USUniversity of America · USCatholic University of America · USHeidelberg University · DEKaplan Medical Center · ILKlinikum Hanau · DE

Funding

Altered Lipid Droplet Trafficking: Role in Alcoholic Fatty Liver DiseaseR01AA020735 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CASEY, CAROL A., MC NIVEN, MARK A. · 2011 to 2025
$8.1M
Alcohol-induced changes in protein acetylation: mechanisms and consequencesR01AA017626 · NIAAA · CATHOLIC UNIVERSITY OF AMERICA · PI PAMELA L. TUMA · 2010 to 2026
$3.0M
Extracellular vesicles as the vehicles for promoting liver injury induced by HIV and alcoholR01AA027189 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI OSNA, NATALIA ALEKSANDR, POLUEKTOVA, LARISA Y · 2019 to 2023
$2.6M
Impaired phospholipid methylation results in decreased lipid droplet lipolysis: Role in hepatic steatosisR01AA026723 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KHARBANDA, KUSUM K. · 2018 to 2022
$1.6M
Ethanol suppresses HBV peptide-MHC Class I presentation on hepatocytesK01AA026864 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GANESAN, MURALI · 2018 to 2022
$684k
Hepatocyte-hepatic stellate cell axis in potentiation of alcohol and HIV-induced liver injuryF31AA028743 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI NEW-AARON, MOSES O · 2021 to 2022
$86k
Impaired methylation alters lipid droplet dynamics in liver and adipose tissue: Role in hepatic steatosisI01BX004053 · VA · OMAHA VA MEDICAL CENTER · PI KHARBANDA, KUSUM K. · 2019 to 2023
–
BLRD VA I01 BX004053BLRD VA I01 BX004171NIAAA NIH HHS F31 AA028743NIAAA NIH HHS K01 AA026864NIAAA NIH HHS R01 AA017626NIAAA NIH HHS R01 AA020735NIAAA NIH HHS R01 AA026723NIAAA NIH HHS R01 AA027189
6 · The paper itself

Abstract

The present review is based on the research presented at the symposium dedicated to the legacy of the two scientists that made important discoveries in the field of alcohol-induced liver damage: Professors C.S. Lieber and S.W. French. The invited speakers described pharmacological, toxicological and patho-physiological effects of alcohol misuse. Moreover, genetic biomarkers determining adverse drug reactions due to interactions between therapeutics used for chronic or infectious diseases and alcohol exposure were discussed. The researchers presented their work in areas of alcohol-induced impairment in lipid protein trafficking and endocytosis, as well as the role of lipids in the development of fatty liver. The researchers showed that alcohol leads to covalent modifications that promote hepatic dysfunction and injury. We concluded that using new advanced techniques and research ideas leads to important discoveries in science.

Indexed as

Liver Diseases, AlcoholicTranslational Research, BiomedicalEthanolHumansLiverEthanolAcetylationAlcoholic liver diseaseHuman immunodeficiency virusHyaline Bodies, Lipid and protein trafficInflammationNonalcoholic liver diseaseNutritionTissue culture

Identifiers

PMID35192844
PMCPMC9167794
OpenAlexW4212825392

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.