ArticleNeuroImage2022
Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms.Molecular psychiatry · 2026Review
- Microstructural changes in locus coeruleus-cortical projections in aged bonnet macaques are independent of myelin loss.Neurobiology of aging · 2026Article
- Microstructural assessment of the locus coeruleus-entorhinal cortex pathway and association with ATN markers in cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- Locus coeruleus contrast and diffusivity metrics differentially relate to age and memory performance.Scientific reports · 2024Article
- Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Locus coeruleus features are linked to vagus nerve stimulation response in drug-resistant epilepsy.Frontiers in neuroscience · 2024Article
- Exploring the Role of Locus Coeruleus in Alzheimer's Disease: a Comprehensive Update on MRI Studies and Implications.Current neurology and neuroscience reports · 2023Review
- The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance.Nature aging · 2023Article
- From neurotransmitters to networks: Transcending organisational hierarchies with molecular-informed functional imaging.Neuroscience and biobehavioral reviews · 2023Review
- State-of-the-art imaging of neuromodulatory subcortical systems in aging and Alzheimer's disease: Challenges and opportunities.Neuroscience and biobehavioral reviews · 2023Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
The noradrenergic locus coeruleus (LC) is a small brainstem nucleus that promotes arousal and attention. Recent studies have examined the microstructural properties of the LC using diffusion-weighted magnetic resonance imaging and found unexpected age-related differences in fractional anisotropy - a measure of white matter integrity. Here, we used two datasets (Berlin Aging Study-II, N = 301, the Leipzig Study for Mind-Body-Emotion Interactions, N = 220), to replicate published findings and expand them by investigating diffusivity in the LC's ascending noradrenergic bundle. In younger adults, LC fractional anisotropy was significantly lower, compared to older adults. However, in the LC's ascending noradrenergic bundle, we observed significantly higher fractional anisotropy in younger adults, relative to older adults. These findings indicate that diffusivity in the LC versus the ascending noradrenergic bundle are both susceptible to structural changes in aging that have opposing effects on fractional anisotropy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.