ArticleCardiovascular diabetology2022
Atherogenic index of plasma for non-diabetic, coronary artery disease patients after percutaneous coronary intervention: a prospective study of the long-term outcomes in China.
Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Association between atherogenic index of plasma and various metabolic conditions: an umbrella review on meta-analyses.BMC cardiovascular disorders · 2025Pooled it
- Atherogenic index of plasma and the clinical outcome of patients with acute coronary syndrome: a meta-analysis.Annals of medicine · 2025Pooled it
- Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies.Cardiovascular diabetology · 2025Pooled it
- The association of atherogenic index of plasma with cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis.Cardiovascular diabetology · 2024Pooled it
- Association between the Atherogenic Index of Plasma and in-Hospital Mortality in Individuals with Sepsis.Yonsei medical journal · 2026Article
- The association between atherogenic index of plasma and postoperative delirium in cardiac surgery patients: an analysis of the MIMIC-IV database.Perioperative medicine (London, England) · 2026Article
- Atherogenic Index of Plasma for the Prediction of Delirium in ICU Patients: A Retrospective Cohort Study Based on the MIMIC-IV Database.Brain and behavior · 2026Article
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- Association between the atherogenic index of plasma and major adverse cardiovascular events in individuals with metabolic syndrome: findings from the UK biobank.Cardiovascular diabetology · 2025Article
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- Association of cumulative changes in atherogenic index of plasma and its obesity-related derivatives with cardiovascular disease: emphasis on incremental risk of diabetes status.Cardiovascular diabetology · 2025Article
- Serum Uric Acid in the PAMELA Study: Main Findings and Association with the Atherogenic Index of Plasma.Metabolites · 2025Review
- Observational
- Association between the atherogenic index of plasma and major adverse cardiovascular events in patients with premature coronary artery disease.European journal of medical research · 2025Article
- Associations of the atherogenic index of plasma with 28-day in-hospital mortality in patients with acute myocardial infarction: a retrospective cohort study from the eICU.Lipids in health and disease · 2025Article
- Role of Nutritional Status in Acute Coronary Syndrome Patients with Diabetes.Medicina (Kaunas, Lithuania) · 2025Article
- Can the Atherogenic Index of Plasma (AIP) Be a Prognostic Marker for Good Clinical Outcome After Mechanical Thrombectomy for Acute Ischemic Stroke?Diagnostics (Basel, Switzerland) · 2025Article
- Atherogenic Index of Plasma (AIP) as a Long-Term Prognostic Factor Following CABG: Unveiling Insights From a Large-Scale Tertiary Center Registry Analysis.Health science reports · 2025Article
- Atherogenic index of plasma and cardiovascular outcomes in female patients undergoing percutaneous coronary intervention: insights from a retrospective cohort study.Scientific reports · 2025Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundNon-diabetic coronary artery disease (CAD) patients are thought to encounter metabolic dysfunction and while these changes may be imperceptible to the patient they probably influence outcomes. At present, there is no system to support patients sensing these subtle changes, nor is there an established model for prognoses. The Atherogenic Index of Plasma (AIP) index has already proven useful for atherosclerosis although further research is needed, especially for those without hyperglycemia.
methodsThis is a prospective study of 5538 non-diabetic CAD patients who had received percutaneous coronary intervention (PCI). Participants were assigned to one of three groups according to their AIP index. High AIP index cases were then compared to low index patients according to major adverse cardiac events (MACE). Restricted cubic spline (RCS) analysis was also conducted to investigate interrelations between AIP index levels and hazard ratios (HR) for MACEs.
resultsPatients with a high AIP index encountered metabolic dysfunction compared to those with a low AIP index i.e., higher Body Mass Index (BMI), Total Cholesterol (TC), Triglycerides (TG), and uric acid as well as lower HDL-C. Each of the aforementioned interrelations were significant with p values of less than 0.001. There was also a significant increase in the number of MACEs in the high AIP index group compared to the low AIP index group (HR: 1.37, 95% CI 1.04-1.81; p = 0.025). A J-shaped RCS curve highlighted a change in the HR after the 0.18 juncture (HR per SD: 1.20, 95% CI 0.96-1.50). Further subgroup analysis supported the main findings, all with HRs greater than one.
conclusionThe AIP index could be used in prognostics for non-diabetic CAD patients 2 years after PCI. The relationship between hazard ratio and the AIP index appears to be J-shaped. Although, further multi-center studies designed for non-diabetic patients with potential metabolic dysfunction should be conducted to determine the value of the AIP index.
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