Evidence map›Paper›PMID 35193911›Full record

ArticleBMJ open2022

Associations between use of psychotropic medications and use of hormonal contraception among girls and women aged 15-49 years in Finland: a nationwide, register-based, matched case-control study.

Elena Toffol, Timo Partonen, Oskari Heikinheimo, Anna But, Antti Latvala, Jari Haukka

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elena ToffolDepartment of Public Health, University of Helsinki Faculty of Medicine, Helsinki, Finland elena.toffol@helsinki.fi.ORCID 0000-0001-6757-7355
Timo PartonenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Oskari HeikinheimoDepartment of Obstetrics and Gynaecology, University of Helsinki Faculty of Medicine and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-8671-130X
Anna ButDepartment of Public Health, University of Helsinki Faculty of Medicine, Helsinki, Finland.
Antti LatvalaInstitute of Criminology and Legal Policy, University of Helsinki, Helsinki, Finland.
Jari HaukkaDepartment of Public Health, University of Helsinki Faculty of Medicine, Helsinki, Finland.ORCID 0000-0003-1450-6208
University of Helsinki · FIFinnish Institute for Health and Welfare · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe relationship between the use of contraception and of psychiatric medications is understudied. We examined whether the current and past use of psychotropic medications is associated with the use and type of hormonal contraception (HC).

designNationwide register-based matched case-control study. SETTINGS: All fertile-aged (15-49 years) girls and women living in Finland in 2017; data from several national registers.

participants294 356 girls and women with a redeemed prescription of HC in 2017, and their same-sized control group of non-users (n=294 356) identified through the Prescription Centre.

main outcome measuresAssociations between the use of psychotropic medications and the use of HC, and the type of HC tested in logistic regression models.

resultsAltogether 19.5% of the HC users, and 18% of the HC non-users received at least one prescription for a psychotropic medication in 2017. Among HC users, the proportions of occasional and regular users of psychotropic medications in 2013-2016 were 4.5% and 14.8%, while among HC non-users the respective figures were 4.3% and 14.6%, respectively. In multivariable logistic regression models both the use of psychotropic medications in 2017, and their occasional or regular use between 2013-2016 were associated with higher odds of HC use, although with small to very small effect sizes (ORs between 1.37 and 1.06 and 95% CIs 1.22 to 1.53, and 1.03 to 1.09, respectively). After adjustment for covariates, when fixed combinations of progestogens and oestrogens for systemic use was the reference category, women using almost any class of psychotropic medications had higher odds of using other types of HC.

conclusionsFertile-aged girls and women with current and past use of psychotropic medications have higher odds of using HC, with a specific pattern in the type of contraceptives used. Further research is warranted to examine whether our observations indicate a reduction of unwanted pregnancies in women with psychiatric disorders.

Indexed as

Hormonal ContraceptionPsychotropic DrugsCase-Control StudiesContraceptionFemaleFinlandHumansPregnancyPsychotropic Drugspsychiatrypublic healthreproductive medicine

Identifiers

PMID35193911
PMCPMC8867378
OpenAlexW4212804015

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.