ArticleScience advances2022
Activation of PDGFRA signaling contributes to filamin C-related arrhythmogenic cardiomyopathy.
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Geographical and Ethnic Heterogeneity in Genetic Dilated Cardiomyopathies.International journal of molecular sciences · 2026Pooled it
- A titin truncating variant linked to atrial fibrillation increases atrial profibrotic signalling and cholinergic sensitivity.Cardiovascular research · 2026Article
- Methylation-centric epigenetic regulation in dilated cardiomyopathy: mechanisms, metabolic interplay, and translational potential.Frontiers in cardiovascular medicine · 2026Review
- Genetic Dilated Cardiomyopathy: A Review.Methodist DeBakey cardiovascular journal · 2026Review
- Article
- Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine.Nature reviews. Cardiology · 2025Review
- Automated fast label-free quantification of cardiomyocyte dynamics with raw holograms for cardiotoxicity screening.Biomedical optics express · 2025Article
- Dilated Cardiomyopathy: A Genetic Journey from Past to Future.International journal of molecular sciences · 2024Review
- Integrative proteomic and metabolomic elucidation of cardiomyopathy with in vivo and in vitro models and clinical samples.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Review
- Risk Assessment and Personalized Treatment Options in Inherited Dilated Cardiomyopathies: A Narrative Review.Biomedicines · 2024Review
- Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias.Journal of the American Heart Association · 2024Article
- Defective Biomechanics and Pharmacological Rescue of Human Cardiomyocytes with Filamin C Truncations.International journal of molecular sciences · 2024Article
- Article
- Genetics of Dilated Cardiomyopathy.Annual review of medicine · 2024Review
- Patient-specific iPSC-derived cardiomyocytes reveal aberrant activation of Wnt/β-catenin signaling in SCN5A-related Brugada syndrome.Stem cell research & therapy · 2023Article
- Multicenter clinical and functional evidence reclassifies a recurrent noncanonical filamin C splice-altering variant.Heart rhythm · 2023Article
- Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery.Cell reports. Medicine · 2023Article
- Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.Circulation · 2023Article
- Comprehensive review on gene mutations contributing to dilated cardiomyopathy.Frontiers in cardiovascular medicine · 2023Review
- Structural and signaling proteins in the Z-disk and their role in cardiomyopathies.Frontiers in physiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 2 countries.
Suet Nee ChenUniversity of Colorado Cardiovascular Institute, University of Colorado Anschutz Medical Aurora, CO, USA.ORCID 0000-0002-9519-9416
Chi Keung LamStanford Cardiovascular Institute, Stanford, CA, USA.ORCID 0000-0003-4565-9426
Ying-Wooi WanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4354-7482
Shanshan GaoUniversity of Colorado Cardiovascular Institute, University of Colorado Anschutz Medical Aurora, CO, USA.ORCID 0000-0003-4194-3630
Olfat A MalakStanford Cardiovascular Institute, Stanford, CA, USA.
Shane Rui ZhaoStanford Cardiovascular Institute, Stanford, CA, USA.ORCID 0000-0002-2137-5536
Raffaella LombardiUniversity of Colorado Cardiovascular Institute, University of Colorado Anschutz Medical Aurora, CO, USA.ORCID 0000-0001-5025-6993
Amrut V AmbardekarUniversity of Colorado Cardiovascular Institute, University of Colorado Anschutz Medical Aurora, CO, USA.ORCID 0000-0003-3503-4203
Michael R BristowUniversity of Colorado Cardiovascular Institute, University of Colorado Anschutz Medical Aurora, CO, USA.ORCID 0000-0002-8860-4698
Joseph ClevelandUniversity of Colorado Cardiovascular Institute, University of Colorado Anschutz Medical Aurora, CO, USA.
Marta GigliCardiovascular Department, Azienda Sanitaria-Universitaria Giuliano Isontina (ASUGI), Trieste, Italy.
Gianfranco SinagraCardiovascular Department, Azienda Sanitaria-Universitaria Giuliano Isontina (ASUGI), Trieste, Italy.
Sharon GrawUniversity of Colorado Cardiovascular Institute, University of Colorado Anschutz Medical Aurora, CO, USA.ORCID 0000-0003-4577-1493
Matthew R G TaylorUniversity of Colorado Cardiovascular Institute, University of Colorado Anschutz Medical Aurora, CO, USA.ORCID 0000-0001-9043-0810
Joseph C WuStanford Cardiovascular Institute, Stanford, CA, USA.ORCID 0000-0002-6068-8041
Luisa MestroniUniversity of Colorado Cardiovascular Institute, University of Colorado Anschutz Medical Aurora, CO, USA.ORCID 0000-0003-1116-2286
University of Colorado Anschutz Medical Campus · USCardiovascular Institute of the South · USAzienda Sanitaria Universitaria Integrata di Trieste · ITBaylor College of Medicine · USFederico II University Hospital · IT
Funding
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0MProject 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA · 2019 to 2026
$21.1MGenetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic CardiomyopathyR01HL116906 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MARCUS, FRANK I, MESTRONI, LUISA · 2013 to 2016
$9.2MElucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCsR01HL130020 · NHLBI · STANFORD UNIVERSITY · PI Ronglih Liao, MARK MERCOLA · 2016 to 2026
$7.3MHuman Induced Pluripotent Stem Cells for Cardiovascular Disease ModelingR01HL113006 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2012 to 2025
$6.8MModeling Tyrosine Kinase Inhibitor-Induced Vascular Dysfunction Using Human iPSCsR01HL141851 · NHLBI · STANFORD UNIVERSITY · PI WONG, WING H., WU, JOSEPH C. · 2018 to 2025
$5.7MGenome Editing of Human iPSCs to Study Inherited Hypertrophic CardiomyopathyR01HL126527 · NHLBI · STANFORD UNIVERSITY · PI QI, LEI STANLEY, WU, JOSEPH C. · 2015 to 2022
$5.4MModeling Susceptibility to Chemotherapy-Induced Cardiotoxicity Using Human iPSCsR01HL123968 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS, WU, JOSEPH C. · 2014 to 2021
$4.8MMolecular Epidemiology of Dilated CardiomyopathR01HL069071 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MESTRONI, LUISA · 2002 to 2005
$2.3MWhole genome DNA sequencing to identify novel genes in dilated cardiomyopathyR01HL109209 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI TAYLOR, MATTHEW R · 2012 to 2016
$2.1MCardiomyocyte phenotype and mechanotransduction in Filamin C gene variants causing arrhythmogenic cardiomyopathyR01HL147064 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MESTRONI, LUISA, TAYLOR, MATTHEW R · 2020 to 2023
$2.1MFamilial Dilated Cardiomyopathy:Genetic CharacterizationK23HL067915 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI TAYLOR, MATTHEW R · 2002 to 2006
$653kAmerican Heart Association-American Stroke Association 17GRNT33670495NCATS NIH HHS UL1 TR001082NHLBI NIH HHS K23 HL067915NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL069071NHLBI NIH HHS R01 HL109209NHLBI NIH HHS R01 HL113006NHLBI NIH HHS R01 HL116906NHLBI NIH HHS R01 HL123968NHLBI NIH HHS R01 HL126527NHLBI NIH HHS R01 HL130020NHLBI NIH HHS R01 HL141851NHLBI NIH HHS R01 HL147064
Abstract
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.