ArticleScience advances2022
Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bibliometric analysis of research trends and prospective directions ofFrontiers in microbiology · 2025Pooled it
- Re-engineering insulin for oral delivery: structural modifications, advanced formulation strategies, and future directions.Drug delivery · 2026Review
- Locking in stability: a biocompatible calcium-squarate framework for protein preservation under extreme stress.Chemical science · 2026Article
- Dynamic biomass micro-nanofibre framework for entrapment and clearance of gastrointestinal microplastics.Nature nanotechnology · 2026Article
- Preparation of Platycodin D Microspheres and Their Protective Effects on Type 2 Diabetes Mellitus.Molecules (Basel, Switzerland) · 2026Article
- Glycosylated nanoparticles for oral insulin delivery via glucose transporter to improve intestinal absorption.Journal of nanobiotechnology · 2026Article
- Strategies for overcoming multiple barriers of oral administration of protein and peptide therapeutics.Materials today. Bio · 2026Review
- Food-derived β-lactoglobulin nanofibrils: An efficacy, safe, and scalable solution to overcome oral insulin delivery challenges.Bioactive materials · 2026Article
- Small Intestine-Targeted Long-Acting Oral Insulin Formulation Based on Engineered Milk Protein Nanoparticles.ACS applied bio materials · 2026Article
- Engineering micelles with hydrophilic-lipophilic balance to overcome intestinal barrier for oral therapeutic application.Materials today. Bio · 2025Article
- Oral delivery of teriparatide utilizing biocompatible transferrin-engineered MOF nanoparticles for osteoporosis therapy.Materials today. Bio · 2025Article
- Insights and advances of theranostic nanoscale metal-organic frameworks.Mikrochimica acta · 2025Review
- Site-specific adaptive nanovesicles for oral insulin delivery.Science advances · 2025Article
- Article
- Nanocage-based {SnErRSC advances · 2025Article
- Characterization of Taurocholic Acid Binding With Insulin for Potential Oral Formulation Using Different Methods.Electrophoresis · 2025Article
- Determination of insulin with ultra-performance liquid chromatography tandem mass spectrometry enhanced by Mg-based micromotors.Mikrochimica acta · 2025Article
- Polyzwitterion-branched polycholic acid nanocarriers based oral delivery insulin for long-term glucose and metabolic regulation in diabetes mellitus.Journal of nanobiotechnology · 2025Article
- Nanoparticles with Cell-Penetrating Peptides for Oral Delivery: A Case for Oral Delivery of Insulin.International journal of nanomedicine · 2025Review
- An orally administered glucose-responsive polymeric complex for high-efficiency and safe delivery of insulin in mice and pigs.Nature nanotechnology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral protein delivery is considered a cutting-edge technology to improve patients' quality of life, offering superior patient compliance and convenience compared with injections. However, oral protein formulation has stagnated because of the instability and inefficient penetration of protein in the gastrointestinal tract. Here, we used acid-resistant metal-organic framework nanoparticles (UiO-68-NH
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.