Evidence map›Paper›PMID 35196402›Full record

ReviewExperimental dermatology2022

Single-cell transcriptomics in human skin research: available technologies, technical considerations and disease applications.

Georgios Theocharidis, Stavroula Tekkela, Aristidis Veves, John A McGrath, Alexandros Onoufriadis

Abstract readReview
In one paragraph

Review in Experimental dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
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  11. Review
  12. Article
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  14. Blank Spots in the Map of Human Skin: The Challenge for Xenotransplantation.International journal of molecular sciences · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Peripheral mechanisms of peripheral neuropathic pain.Frontiers in molecular neuroscience · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Georgios TheocharidisJoslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-8895-9130
Stavroula TekkelaSt John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK.ORCID 0000-0003-0827-6426
Aristidis VevesJoslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-3901-4405
John A McGrathSt John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK.ORCID 0000-0002-3708-9964
Alexandros OnoufriadisSt John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK.ORCID 0000-0001-5026-0431

Funding

Department of Health
6 · The paper itself

Abstract

Single-cell technologies have revolutionized research in the last decade, including for skin biology. Single-cell RNA sequencing has emerged as a powerful tool allowing the dissection of human disease pathophysiology at unprecedented resolution by assessing cell-to-cell variation, facilitating identification of rare cell populations and elucidating cellular heterogeneity. In dermatology, this technology has been widely applied to inflammatory skin disorders, fibrotic skin diseases, wound healing complications and cutaneous neoplasms. Here, we discuss the available technologies and technical considerations of single-cell RNA sequencing and describe its applications to a broad spectrum of dermatological diseases.

Indexed as

Single-Cell AnalysisTranscriptomeGene Expression ProfilingHumansSequence Analysis, RNATechnologyscRNA-seqsingle-cell sequencingsingle-cell transcriptomicsskin research

Identifiers

PMID35196402
PMCPMC9311140

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.