Evidence map›Paper›PMID 35200532›Full record

ArticleMethods and protocols2022

Development of Primary Monolayer Cell Model and Organotypic Model of Uterine Leiomyoma.

Natalia Shved, Anna Egorova, Natalia Osinovskaya, Anton Kiselev

Open access · goldAbstract read
In one paragraph

Article in Methods and protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Natalia ShvedDepartment of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, MendeleevskayaLine 3, 199034 Saint-Petersburg, Russia.
Anna EgorovaDepartment of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, MendeleevskayaLine 3, 199034 Saint-Petersburg, Russia.
Natalia OsinovskayaDepartment of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, MendeleevskayaLine 3, 199034 Saint-Petersburg, Russia.
Anton KiselevDepartment of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, MendeleevskayaLine 3, 199034 Saint-Petersburg, Russia.ORCID 0000-0002-2487-2423
Research Institute of Obstetrics and Gynecology named after D.O. Ott · RU

Funding

Russian Science Foundation 21-15-00111
6 · The paper itself

Abstract

Cellular technologies are one of the most promising areas of biomedicine, which is based on the isolation of cells of various types, followed by their cultivation and use, or the use of their metabolic products, for medical purposes. Today, a significant part of biomedical research is carried out in vitro. On the other hand, organotypic culture can be used as a powerful model system and can complement cell culture and in vivo studies in different biomedical applications. Uterine leiomyoma (UL) is a very common benign tumor and often leads to many reproductive complications. Herein we describe a fast and reliable method of isolation and UL primary cells culturing along with the development of a UL organotypic model. We propose the usage of UL primary cells in experimental work at a first passage to prevent loss of driver mutations in

Indexed as

cell modelHMGA2MED12organotypic modeluterine leiomyoma

Identifiers

PMID35200532
PMCPMC8875914
OpenAlexW4210815648

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.