Evidence map›Paper›PMID 35203377›Full record

ArticleCells2022

Epigenetic Dysregulation of the

Luca Parrillo, Rosa Spinelli, Mattia Costanzo, Pasqualina Florese, Serena Cabaro, Antonella Desiderio, Immacolata Prevenzano, Gregory Alexander Raciti, Ulf Smith, Claudia Miele and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Luca ParrilloDepartment of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy.ORCID 0000-0001-9801-9778
Rosa SpinelliDepartment of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy.ORCID 0000-0001-7308-4119
Mattia CostanzoDepartment of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy.
Pasqualina FloreseDepartment of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy.
Serena CabaroDepartment of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy.
Antonella DesiderioDepartment of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy.ORCID 0000-0002-3510-7663
Immacolata PrevenzanoDepartment of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy.
Gregory Alexander RacitiDepartment of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy.ORCID 0000-0003-2742-5634
Ulf SmithLundberg Laboratory for Diabetes Research, Department of Molecular & Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden.
Claudia MieleDepartment of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy.
Pietro FormisanoDepartment of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy.
Raffaele NapoliDepartment of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy.ORCID 0000-0002-3366-2321
Francesco BeguinotDepartment of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy.
Institute for Experimental Endocrinology and Oncology · ITUniversity of Gothenburg · SEUniversity of Naples Federico II · IT

Funding

Ministero dell'Istruzione, Università e della Ricerca Scientifica PRIN 2017Regione Campania POR FESR 2014-2020 - Obiettivo Specifico 1.2. - "Manifestazione di Interesse per la Real-izzazione di Technology Platform nell'ambito della Lotta alle Patologie Oncologiche" - Projects COEPICA, RARE PLAT NET and SATIN
6 · The paper itself

Abstract

Along with insulin resistance and increased risk of type 2 diabetes (T2D), lean first-degree relatives of T2D subjects (FDR) feature impaired adipogenesis in subcutaneous adipose tissue (SAT) and subcutaneous adipocyte hypertrophy well before diabetes onset. The molecular mechanisms linking these events have only partially been clarified. In the present report, we show that silencing of the transcription factor

Indexed as

Diabetes Mellitus, Type 2Homeodomain ProteinsObesityTranscription FactorsAdipocytesEpigenesis, GeneticGenes, HomeoboxHumansHypertrophyHomeodomain ProteinsHOXA5 protein, humanTranscription Factorsadipocyte hypertrophyadipose tissueDNA methylationepigenetic marksgene expressionhuman adipogenesisobesitypreadipocyteT2D familiaritytranscription factors

Identifiers

PMID35203377
PMCPMC8870634
OpenAlexW4213051929

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.