ArticleAntioxidants (Basel, Switzerland)2022
Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized
2 registry-linked trialsOpen access · goldAbstract read
In one paragraph
Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
9.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pharmacokinetic Study of Centella Asiatica Product (CAP) in Elderly Participants With Mild Cognitive Impairment Receiving Cholinesterase Inhibitor Therapy
Safety and Target Engagement of Centella Asiatica in Cognitive Impairment
Who cites it
32 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of Long-Term Supplementation withNutrients · 2026Trial
- Efficacy and safety ofFrontiers in pharmacology · 2025Trial
- Therapeutic potential ofPharmaceutical biology · 2026Review
- Plant-derived phytochemicals for Alzheimer's disease: mechanisms of action, experimental evidence, and therapeutic perspectives.Journal of natural medicines · 2026Review
- Investigating the Role of Phenolic Acid Coformers in Enhancing the Physicochemical Properties of Enzalutamide Coamorphous Systems.The AAPS journal · 2026Article
- Translational potential of medicinal plants for Alzheimer's disease: integrated evidence from molecular mechanisms to preclinical and clinical findings.Natural products and bioprospecting · 2026Review
- Withanolides Are Detected in Human Urine Following Oral Administration of aInternational journal of molecular sciences · 2026Article
- Multitarget Actions of Pentacyclic Triterpenic Acids in Alzheimer's Disease: Mechanistic Insights.Molecules (Basel, Switzerland) · 2026Review
- Unlocking the Power of Plant-Derived Natural Products: Therapeutic Benefits for Cognitive Health and Neuropsychiatric Symptoms in Dementia-Related Diseases.Plants (Basel, Switzerland) · 2026Review
- Geroprotective Potential ofNutrients · 2026Review
- Natural Products Targeting Angiogenesis and Tumor Microenvironment in Gastrointestinal Malignancies.Cells · 2026Review
- A standardized extract of Centella asiatica (ECa 233) alleviates brain injury and improves brain function in β-thalassemia mice with iron overload.BMC complementary medicine and therapies · 2025Article
- Neuronutrition and Nrf2 Brain Resilience Signaling: Epigenomics and Metabolomics for Personalized Medicine in Nervous System Disorders from Bench to Clinic.International journal of molecular sciences · 2025Review
- Targeting the Milieu in Neurodegenerative Disease: Time for "Imprecision Medicine"?Aging and disease · 2025Review
- Nutraceutical Strategies for Targeting Mitochondrial Dysfunction in Neurodegenerative Diseases.Foods (Basel, Switzerland) · 2025Review
- Integrative approaches in Alzheimer's disease: evaluating the potential of traditional, complementary, and integrative medicine (TCIM).Frontiers in pharmacology · 2025Review
- Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Review
- Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms.Aging and disease · 2024Review
- The role of Nrf2 signaling pathways in nerve damage repair.Toxicology research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Kirsten M WrightDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0002-6913-7422
Melissa BollenDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.
Jason DavidDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.
Alex B SpeersDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0001-5580-3298
Mikah S BrandesDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.
Nora E GrayDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.
Armando Alcázar MagañaDepartment of Chemistry, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0002-4731-0247
Christine McClureDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.
Jan F StevensDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0002-6348-9347
Claudia S MaierDepartment of Chemistry, Oregon State University, Corvallis, OR 97331, USA.
Joseph F QuinnDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0001-7305-2256
Amala SoumyanathDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0003-1569-6453
Oregon Health & Science University · USOregon State University · US
Funding
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4MResearch Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KEVIN M DUFF, Lisa C Silbert · 2020 to 2026
$28.6MOutreach, Recruitment and Education CoreP30AG008017 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAYE, JEFFREY A · 1990 to 2019
$27.7MOregon Clinical and Translational Research Institute KL2 SupplementKL2TR002370 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Catherine Lee Hough · 2017 to 2026
$10.1MCAM Research Training in Neuroscience &StressT32AT002688 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI OKEN, BARRY S, SOUMYANATH, AMALA · 2005 to 2025
$7.2MBiological signatures of the cognitive effects of Centella asiaticaR61AT009628 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI QUINN, JOSEPH F, SOUMYANATH, AMALA · 2017 to 2019
$522kTriple Quadrupole/Linear Ion Trap LC-MS/MS for LPIS10RR027878 · NCRR · OREGON STATE UNIVERSITY · PI STEVENS, JAN FREDERIK · 2010 to 2010
$484kNCATS NIH HHS KL2 TR002370NCATS NIH HHS UL1 TR002369NCATS NIH HHS UL1TR002369NCCIH NIH HHS KL2TR002370-03S1NCCIH NIH HHS R61AT009628NCCIH NIH HHS T32 AT002688NCCIH NIH HHS T32AT002688NCRR NIH HHS S10RR027878NIA NIH HHS P30AG008017NIA NIH HHS P30 AG066518
Abstract
PubMed holds no abstract for this paper.
Indexed as
Alzheimer’s diseaseantioxidantCentella asiaticaNRF2pharmacodynamicspharmacokineticstolerability
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT03937908ClinicalTrials.gov
NCT05591027ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.