Evidence map›Paper›PMID 35204233›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Lysophosphatidic Acid Receptor 3 Promotes Mitochondrial Homeostasis against Oxidative Stress: Potential Therapeutic Approaches for Hutchinson-Gilford Progeria Syndrome.

Jui-Chung Chiang, Wei-Min Chen, Ciara Newman, Benjamin P C Chen, Hsinyu Lee

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Geopropolis fromPharmaceuticals (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Frontiers in aging · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jui-Chung ChiangDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-9979-8347
Wei-Min ChenDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-5247-7826
Ciara NewmanDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-6775-7732
Benjamin P C ChenDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Hsinyu LeeDepartment of Life Science, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0002-1477-0183
National Taiwan University · TWThe University of Texas Southwestern Medical Center · US

Funding

DNA-PKcs and PIDD interaction in DNA damage responseR01CA233594 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI DAVIS, ANTHONY J · 2019 to 2023
$1.8M
NCI NIH HHS R01 CA233594NIH HHS CA233594Taiwan Ministry of Science and Technology 110-2311-B-002-026Taiwan Ministry of Science and Technology 110-2926-I002-509
6 · The paper itself

Abstract

Lysophosphatidic acid (LPA) is a growth factor-like lipid mediator that regulates various physiological functions via activation of multiple LPA G protein-coupled receptors. We previously reported that LPA suppresses oxidative stress in premature aging Hutchinson-Gilford progeria syndrome (HGPS) patient fibroblasts via its type 3 receptor (LPA

Indexed as

Hutchinson-Gilford progeria syndromelysophosphatidic acidmitochondrial homeostasisoxidative stress

Identifiers

PMID35204233
PMCPMC8869156
OpenAlexW4211112854

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.